ChREBP is a key lipogenic
transcription factors responsible for the induction of gene encoding enzymes involved in fatty acid and triacylglyceride synthesis in the liver (Filhoulaud et al., 2013).
Most of the studies have focused on isolipidic diets evaluation, testing different degrees of soybean oil substitution, nevertheless, those studies do not consider the effects between lipid levels and source type on parameters such as growth, survival, activity of digestive enzymes and expression of lipogenic
genes, particularly during larval stages.
Influence of piglet birth weight on postnatal growth performance, tissue lipogenic
capacity and muscle histological traits at market weight.
Literature review shows that both undifferentiated adipose tissue stem cells and bone marrow derived mesenchymal stem cells have osteogenic, chondrogenic and lipogenic
differentiation potential which can help in defect repair in reconstructive surgeries.
Stearoyl-coA desaturase 1 gene expression is necessary for fructose-mediated induction of lipogenic
gene expression by sterol regulatory element-binding protein-1c-dependent and -independent mechanisms.
Upstream regulators of de novo lipogenesis (i.e., carbohydrate response element-binding protein [ChREBP] and sterol regulatory element-binding protein 1c [SREBP-1c]) were measured by polymerase chain reaction and key lipogenic
enzymes (acetyl-CoA carboxylase [ACC], fatty acid synthase [FAS], and stearoyl-CoA desaturase-1 [SCD-1]) by Western blotting.
The changes in muscle FAs due to feeding strategies are implicated in the expression of lipogenic
Accordingly, there is increasing evidence that RT stimulates lipid oxidation in the liver due to the activation of AMP-activated protein kinase (AMPK) (6, 35, 38) and down regulation of lipogenic
gene expression by liver enzymes (39).
In this sense, there is evidence that RT stimulates lipid oxidation, due to the activation of protein kinase (AMP) and the negative regulation of the pathway of lipogenic
enzymes by expression of the hepatic gene (9,18).
Vannucchi, "Fish oil decreases hepatic lipogenic
genes in rats fasted and refed on a high fructose diet," Nutrients, vol.
The triglyceride lowering effect could explain at least in part the inhibition of de novo fatty acid synthesis and downregulation of lipogenic
enzymes as has been suggested for oligofructose .