Adaptimmune Therapeutics has started its SPEARHEAD-1 trial with ADP-A2M4 SPEAR T-cells for patients with synovial sarcoma or myxoid/round cell liposarcoma
. Earlier this year, Adaptimmune presented compelling data with responses observed in synovial sarcoma patients treated in the ADP-A2M4 pilot study.
The ATG-010 is a first-in-class selective inhibitor of nuclear export (SINE) compound in late clinical development to treat multiple haematological malignancies and solid tumours such as multiple myeloma, diffuse large B-cell lymphoma and liposarcoma
. ATG-008 is a second generation TORC1/2 inhibitor, which is currently in development to treat hepatitis B virus positive (HBV+) hepatocellular carcinoma.
Its ATG-010 (selinexor) is a first-in-class Selective Inhibitor of Nuclear Export (SINE) compound in late clinical development for the treatment of multiple hematological malignancies and solid tumours, including multiple myeloma, diffuse large B-cell lymphoma and liposarcoma
is the most heterogeneous of all sarcomas with a wide variety of histologic patterns including tumors with distinctive patterns, tumors with heterologous and homologous differentiation, and lowgrade tumors.
Computer tomography revealed a giant pelvic mass which lead to left side hydronephrosis, hydrouterer and a pear-shaped bladder, with the differential diagnosis including pelvic lipoma or liposarcoma
. An ultrasound guided biopsy excluded the diagnosis of liposarcoma
arising in the background of well-differentiated liposarcoma
, with MDM2 gene amplification detected on fluorescent in-situ hybridization (FISH) testing.
Rarely, a lump that appears to be a benign lipoma may be a type of cancer called a liposarcoma
; that's why it is important to undergo testing, such as an MRI or CT scan and/or a biopsy, to confirm that the lump is noncancerous.
The differential diagnosis for lipoma includes liposarcoma
and fibrolipomatous hamartoma.
Atypical lipomatous tumor (ALT) and well-differentiated liposarcoma
(WDL) are rare liposarcoma
subtypes that are histologically identical but distinguished by the 2002 WHO classification: ALTs occur in surgically amenable locations, whereas WDLs do not.
The New Jersey financial planner was later diagnosed with liposarcoma
, a rare form of cancer that develops in the fat cells of the soft tissues.
, Pericardial mass, Primary pericardial tumour.
Malignant change of lipoma to liposarcoma
is almost never seen.