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This has a characteristic histopathological pattern of a lobular panniculitis with small droplets of silicone oil found within the vacuoles and giant multinucleated cells [10, 11].
Histological findings associated with drug-induced panniculitis can range from septal panniculitis with a lympho-histiocytic infiltrate to lobular panniculitis with a mixed or mostly neutrophilic infiltrate particularly with tyrosine kinase inhibitors (10).
Early injected lesions usually show a brisk neutrophilic lobular panniculitis with fat necrosis (Figure 6, A), (34,36,37) which in some cases may be indistinguishable from infective panniculitis.
SCFN characteristically shows a lobular panniculitis with a dense infiltrate of lymphocytes, histiocytes, multinucleated giants cells and occasional eosinophils, and radially arranged needle-shaped clefts in adipocytes and histiocytes.
Histopathology of biopsy from the lesion of right cheek showed epidermal atrophy, hydropic degeneration of the basal cell layer, perivascular and periappendageal lymphocytic infiltration, a lobular panniculitis with dense infiltrates of lymphocytes and macrophages, and focal hyalinization of the adipocytes (Figure 3 and Figure 4).
Lobular panniculitis with an inflammatory infiltrate, predominantly composed of lymphocytes, occurs often.
Our patient, a 57-year-old man, presented with cutaneous lesions in his legs, characterized by lobular panniculitis (PN) with fat necrosis and ghost cells.
The post-irradiation sclerodermatous panniculitis histological pattern reveals significant changes in the subcutaneous tissues with lobular panniculitis. The dermis is nearly unaffected (9).