PARIS--The inhaled powder formulation of loxapine
appears to be a safe and effective treatment for acute agitation in patients with personality disorders, Diego R.
Previous limited case reports have shown loxapine
to be effective in treating individuals with refractory schizophrenia, either alone or in combination with other antipsychotics.
Addressing the need for rapid treatment of agitation in schizophrenia and bipolar disorder: focus on inhaled loxapine
as an alternative to injectable agents.
was introduced to the market over 25 years ago in several countries, including the United States and Canada and in Europe.
This seems to be the reasoning behind the ongoing and past development of a variety of pulmonary formulations of well-characterized CNS agents, notably fentanyl for the treatment of acute onset pain, and loxapine
Prescribed typical antipsychotics within the study period included chlorpromazine, clopenthixol, clothiapine, droperidol, flupentixol, fluphenazine, haloperidol, levomepromazine, loxapine
, methotrimeprazine, perphenazine, pipotiazine, sulpiride, thioridazine, thiothixene, and trifluoperazine.
10,11) The drugs implicated are phenothiazines (especially chlorpromazine), thiothixene, fluphenazine, fluspirilene, loxapine
Recently, the Food and Drug Ad ministration approved an inhaled power formulation of loxapine
(Adasuve) for the treatment of agitation in bipolar disorder and schizophrenia.
psychotic drug produced by Arwan will be exported to the Gulf and the whole MENA region, where the company is registered.
She had been on olanzapine for about 1 year and then, due to objectionable side effects, was switched to 5 mg of loxapine
5-10 mg Medium Potency Trifluoperazine Stelazine 1-10 mg Typical Perphenazine Trilafon 2-16 mg Thiothixene Navane 2-20 mg Loxapine
Loxitane 5-50 mg Low Potency Molindone Moban 5-100 mg Typical Mesoridazine Serentil 10-100 mg Thioridazine Mellaril 10-200 mg Chlorpromazine Thorazine 10-200 mg Adapted from Wilens (1999) and Li, Pearrow, & Jimerson (2010).
However, the cognitive status of this latter patient seems to be much worse than our patient, and she received loxapine
and haloperidol over longer periods of time.