The presentations will focus on recently completed studies designed to determine drug concentration and release characteristics for DARE-HRT1 and DARE-FRT1, novel intravaginal ring drug delivery product candidates containing bio-identical hormones being developed for the treatment of menopause-related vasomotor symptoms and luteal
phase pregnancy maintenance, respectively.
Other important explanation for decreased PR following resynchronization protocol is that 15-26% animals don't have functional luteal
tissue leading to suboptimal P4 in circulation (Silva et al., 2009; Sterry et al., 2006; Fricke et al., 2003).
This may be mainly due to the normal hormonal disturbances that occur during the late luteal
phase of the menstrual cycle.
Therefore, a progesterone supplement is administered during the luteal
phase to achieve optimal endometrial receptivity (4).
Another interesting report by Clementi and coworkers  also suggests that the luteotropic effect of the decidual tissue in rats is mediated through the secretion of pituitary PRL, which in turn stimulates P4 biosynthesis by increasing luteal
3[beta]-HSD activity, and inhibits P4 catabolism by diminishing luteal
The flexibility and MDS tests were also performed during the ovulation (14th day of the MC) and luteal
(26th - 28th days of the MC) phases.
In many women who have a primary mood or anxiety disorder, the late luteal
phase is a vulnerable time.
Whilst the mechanism responsible for this effect is likely to be at least partially related to energy supply it is also considered to involve the inhibition of prostaglandin synthesis by fat-derived hnoleic acid , Moreover, micronutrients are also considered to contribute to luteal
function, e.g., Kawashima et al  reported that [beta]-carotene supply supports the postpartum reestablishment of luteal
activity in dairy cows, and Arellano-Rodriguez et al  showed that [beta]-carotene enhances ovarian function and P4 synthesis in goats.
3, 4 Oestrogen and progesterone receptors both increase endometrial glands and stroma during follicular and early luteal
phases of a normal menstrual cycle.
In addition, progesterone level in early luteal
period has essential role in maintaining pregnancy.
Previous research studies have compared the tongue colors of healthy subjects in the luteal
and follicular phases .
We present here a case of OHSS resulting from luteal
phase use of hCG and highlight the danger of pursuing such protocols in the circumstances of a patient at high risk of OHSS.