However, LH increases the aromatase activity in follicular development by having a synergistic interaction with FSH, and thus the estrogen secretion increases and ovulation and luteinization
are ensured (7).
It was the lack of robust luteinization
of the cells that Dr Scully used to explain the usual lack of function of these tumors; a more typical luteinized nature with abundant eosinophilic cytoplasm is usually seen in pregnancy.
In addition to that, GDF9 stimulate follicular growth, granulosa cells luteinization
and maintain normal follicular environment in sheep (Juengel et al.
This LH surge activates proteolytic enzymes which leads to follicular rupture and causes luteinization
of the granulosa and theca cells, resulting in a marked increase in progesterone production.
Due to luteinization
of ruptured Graffian follicles and absence of new growing follicles, E2 concentrations tend to gradually decline during gestational period .
Luteal cysts occurred more frequently in January to March 2015 (Figure 2), indicating a luteinization
of the follicular cysts that occurred in the previous months.
A narrow rim of ovarian stroma with luteinization
was present along the outer surface (Figure 1).
In fact, Richards and coworkers have documented a significant increase both in P450scc and 3[beta]-HSD transcript levels in luteal cells during the luteinization
process [9, 10].
On histopathological assessment, polycystic ovaries contain increased numbers of follicles, hypertrophy and luteinization
of the inner theca cell layer, and a thickened ovarian tunica (5).
Treatment with the GnRH antagonist Ganirelix prevents premature LH rises and luteinization
in stimulated intrauterine insemination: results of a double-blind, placebo-controlled, multicentre trial.
Regulation of late follicular development, ovulation and luteinization
: The human menstrual cycle.
Macrophages are able to regulate cellular proliferation, differentiation and apoptosis, as well as influence steroid production, vascularization and tissue remodelling during follicle growth, ovulation and luteinization
. It is important to consider that the marker used to identify macrophages reveals specific information about the changing functional characteristics of the cells; for instance, in the rabbit, luteolysis was associated with an initial increase in scavenger receptor positive macrophages followed by recruitment of CD68 positive macrophages (Song et al.).