Although age at puberty varies widely between and among mammalian species, the main event that signals puberty onset is basically similar, in that it relies on the increased pulsatile secretory activity of a hypothalamic neuropeptide, luteinizing
hormone-releasing hormone (LHRH).
The effects of immunization against luteinizing
hormone-releasing hormone on performance, gexual development, and levels of boar taint-related compounds in intact male pigs.
The positive CHMP opinion is based on results from the TERRAIN study, which enrolled 375 patients in North America and Europe with metastatic prostate cancer whose disease progressed despite treatment with a luteinizing
hormone- releasing hormone (LHRH) analogue therapy or following surgical castration.
In the study, researchers examined pulses of luteinizing
hormone (LH) secretion in relation to specific sleep stages in children ages 9-15.
Ozarelix is a luteinizing
hormone-releasing hormone (LHRH) antagonist.
Serum levels of luteinizing
hormone, follicle-stimulating hormone, prolactin, 17-alpha hydroxyprogesterone, testosterone and 17-beta estradiol were measured before and at 2, 4, 8 and 12 weeks of treatment with placebo or Maca (1.
hormone releasing-hormone agonists are also used in a neoadjuvant fashion in men undergoing brachytherapy who require prostate gland downsizing.
There was no significant difference between groups in levels of follicle stimulating hormone, luteinizing
hormone, estradiol, sex hormone-binding globulin, and progesterone.
7,846,898, "Pheromones and the luteinizing
hormone for inducing proliferation of neural stem cells and neurogenesis").
It has been suggested that hyperinsulinemia and luteinizing
hormone together could induce the changes that lead to polycystic ovary morphology, such as ovarian stroma and theca interna hyperplasia, and could contribute to menstrual dysfunction in adolescent girls, she said.
Several companies market highly accurate ovulation tests that read concentrations of luteinizing
hormones in urine to let a woman identify a two- or three-day window of opportunity, but there are now other--reportedly more accurate--ways of predicting fertility.
The drug, most frequently used for prostate cancer, endometriosis, and precocious puberty, decreases levels of luteinizing
hormone--an action that has been shown to decrease the rate of cognitive decline and amyloid accumulation in an Alzheimer's mouse model.