With a targeted mechanism of action, bempedoic acid is a first-in-class, ATP Citrate Lyase
(ACL) inhibitor that reduces cholesterol biosynthesis and lowers LDL-C by up-regulating the LDL receptor.
Jack Miller was born with ADSL (Adenylosuccinate lyase
) deficiency, which means he is unable to speak or move around.
Phenylalanine ammonia lyase
activity in tomato seedlings and its relationship to bacterial canker disease resistance.
Palynziq, a PEGylated recombinant phenylalanine ammonia lyase
enzyme, is the first enzyme substitution therapy approved in Europe to target the underlying cause of PKU by helping the body to break down Phe.
ASA is a rare genetic urea cycle disorder characterised by deficiency or lack of the enzyme argininosuccinate lyase
(ASL), which is central to two metabolic pathways: the liver-based urea cycle, which detoxifies ammonia and the citrulline-nitric oxide cycle, which synthesises nitric oxide from L-arginine.
They used a variety of ingredients as solubility enhancers, such as canola oil, soy lecithin granules, four types of liquids, hydroxymethylglutaryl-CoA lyase
(HMGL) liquid, four types of maltodextrin, modified food starch, xanthan gum and pre-hydrated pectin at 0%, 5%, 10%, 15% and 20% levels.
Bempedoic acid is a first-in-class oral inhibitor of ATP citrate lyase
, an enzyme that is inactive in skeletal muscle--thus, the lack of myalgia complaints--and lies upstream of HMG-CoA reductase in cholesterol synthesis.
Caralluma extract contains pregnane glycosides which are responsible for blocking the activity of citrate lyase
, thus, inhibiting fat synthesis and faster burning of fat.
The absence of 17,20 lyase
activity in the adrenal gland also results in deficiency of DHEA sulfate (DHEA-S), causing failure of adrenarche and pubic and axillary hair development (5,6).
3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) lyase
deficiency is a rare autosomal recessive congenital defect of ketone body synthesis and leucine degradation.
This once-daily pill works in the liver to prevent cholesterol formation by inhibiting a key enzyme called ATP citrate lyase