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A lymphokine that is toxic to certain susceptible target cells.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
References in periodicals archive ?
Etanercept (ETN) is a dimeric, human recombinant fusion protein that binds specifically to tumor necrosis factor (TNF) and lymphotoxin, inhibiting their interaction with cell surface receptors (3, 4).
MHC class II, tumour necrosis factor alpha, and lymphotoxin alpha gene haplotype associations with serological subsets of systemic lupus erythematosus.
Tumor necrosis factor [alpha] and lymphotoxin [alpha] haplotypes in idiopathic recurrent pregnancy loss.
The apparent absence of lymphotoxin genes might explain the lack of lymph nodes in hens, because these genes are crucial to lymph node formation in mammals (KAISER, 2012).
Karin, "B-cell-derived lymphotoxin promotes castration-resistant prostate cancer," Nature, vol.
Interestingly, the treatment of immunotherapy-resistant Ag104Ld tumors with Ab-LIGHT (homologous to lymphotoxin)-based therapy can activate the lymphotoxin [beta] receptor (LT[beta]R) signaling specifically in tumor cells which is leading to enhanced secretion of multiple chemokines.
Sakaguchi et al., "Human lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization," Nucleic Acids Research, vol.
[91] have shown that membrane-bound lymphotoxin and the chemokine receptor CXCR are involved in this process and antagonizing these receptors ameliorates NLRP3-independent EAE.
examined TNF-[alpha], IL-2, IFN-[gamma], IL-6, IL-1[beta], and lymphotoxin levels in the serum of 31 patients with oral lichen planus, and they found only TNF-[alpha] and IL-6 levels higher in patients compared to the control group (12).