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A lymphokine that is toxic to certain susceptible target cells.
References in periodicals archive ?
Autocrine lymphotoxin production in Epstein-Barr virus-immortalized B cells: induction via NF-kappaB activation mediated by EBV-derived latent membrane protein 1.
Synergistic interactions between interleukin 1, tumor necrosis factor, and lymphotoxin in bone resorption.
A trial with the novel agent baminercept, a lymphotoxin beta receptor fusion protein.
The lymphotoxin then interacts with the cells that form the foundation of the actual lymph node -- the so-called "stromal cells.
Binding of IL-2 to the IL-2 receptor on T lymphocytes leads to cell proliferation, increased lymphokine secretion(IFNg, lymphotoxin, IL-4, IL-3, IL-5, GM-CSF), and enhanced expression of class II MHC molecules.
Recently, it is reported that ER stress is able to induce necroptosis in L929 cells in a tumor necrosis factor receptor 1- (TNFR1-) dependent manner, but independent of autocrine TNF or lymphotoxin a production [37].
This signaling is initiated following antigen recognition on MHC-II molecules, whereupon Th1 cells secrete the cytokines IFN-[gamma] and lymphotoxin alpha (LT-[alpha]), a member of the pro-inflammatory TNF family (Weaver et al.
Lymphotoxin beta receptor signaling promotes tertiary lymphoid organogenesis in the aorta adventitia of aged ApoE-/- mice.
The product is a chimeric human murine monoclonal antibody that binds with high affinity to both soluble and transmembrane forms of TNF alpha but not to lymphotoxin a (TNF beta).
Secretion of tumour necrosis factor alpha and lymphotoxin alpha in relation to polymorphisms in the TNF genes and HLA-DR alleles.
Two single-base polymorphisms in the human tumor necrosis factor locus of multiple sclerosis patients from the Russian population: NcoI-RFLP in the first intron of the human lymphotoxin alpha gene correlates with the disease.
45) GPI stimulates the production of TNF-[alpha] and lymphotoxin which further cause upregulation of expression of cytoadherence receptors notably ICAM-1 and VCAM-1 on ECs.