Dietary fortification of a natural biosurfactant, lysolecithin
This is the probable reason for the accumulation of free fatty acids and lysolecithin
at high concentrations.
On the one hand, emulsifiers (lysophospholipids, lysolecithin
, bile salts, or sodium stearoyl-2-lactylate) were used to increase the lipid digestibility because they increased the active surface of lipid droplets and promote incorporation of fatty acids into micelles [7,11,12].
In our previous study, hADSCs were transplanted in lysolecithin
model of MS.
One model used the ingested toxin cuprizone and the other used injected lysolecithin
to achieve demyelination of CNS neurons and spinal nerve axons, respectively.
Blakemore, "Remyelination of mouse spinal cord axons demyelinated by local injection of lysolecithin
," Journal of Neurocytology, vol.
Among these, it is possible to highlight the chemically induced CNS lesions, such as those generated with cuprizone feeding, ethidium bromide injection, and lysolecithin
, or the experimental autoimmune encephalomyelitis (EAE) model, widely used in drug screening as it most faithfully represents the pathology seen in MS .
This decrease may be due to enhanced activity of LCAT (Lysolecithin
Acyl Transferase) which also causes hypertriglyceridemia.
Drugs such as cuprizone and lysolecithin
are frequently used to model multiple sclerosis , as these agents elicit partial demyelination when injected at specific sites in the spinal cord.
Regurgitation of duodenal contents, including alkaline pancreatic-duodenal secretions, bile salts, and lysolecithin
into the gastric cavity may disrupt the gastric mucosa barrier and damage the mucosa epithelium.[sup] Excessive DGR results in accelerated regeneration of epithelium with histological appearance of foveolar hyperplasia and expansion of the smooth muscle fiber in the mucosa.[sup], Patients with DGR had higher intensity of gastric mucosal inflammation.[sup],, Matsuhisa and Tsukui also showed that high concentrations of bile acids were shown to have an effect on the progression of intestinal metaplasia in H.
is generated in LDL particle as a result of the lipid peroxidation, and the concentration of esterified cholesterol is reduced, a number of lipid-derived oxidation products are formed, including lipid hydroperoxides, and specific products of linoleate and arachidonate oxidation are formed, including 9-hydroxy-10,12-octadecadienoic acid (9-HODE) and F2-isoprostanes [70,71].
The term "phospholipase B" was first described by Contardi and Ercoli (1) in 1933 as lecithase B, which attacked an acyl--ester bond of lysolecithin
and produced one mole each of fatty acid and glycerophosphocholine (GPC).