macrocyclic

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Related to macrocyclic: macrocyclic lactones, Macrocyclic compounds

mac·ro·cy·cle

(măk′rō-sī′kəl)

1. A cyclic macromolecule.

2. A molecule or portion of a molecule in which atoms, usually ten or more, are connected in a ring.

mac′ro·cyc′lic (-sĭk′lĭk) adj.

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

macrocyclic

(ˌmækrəʊˈsɪklɪk; ˌmækrəʊˈsaɪklɪk)

adj

(Chemistry) containing or relating to a macrocycle

Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014

mac•ro•cy•clic

(ˌmæk roʊˈsaɪ klɪk, -ˈsɪk lɪk)

adj.

having a ring structure consisting of more than 12 atoms.

[1945–50]

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References in periodicals archive ?

ENPNewswire-August 22, 2019--Ra Pharmaceuticals Earns Clinical Development Milestone for Oral Macrocyclic Peptide Candidate Targeting Cardiovascular Indication Under Agreement with Merck

Ra Pharmaceuticals Earns Clinical Development Milestone for Oral Macrocyclic Peptide Candidate Targeting Cardiovascular Indication Under Agreement with Merck

(NYSE:MRK) following the dosing of the first patient in a Phase 1 trial evaluating an investigational orally-available macrocyclic peptide for a non-complement cardiovascular target.

The Daily Biotech Pulse: Ra Medical Earns Milestone, Aimmune Doses Patient In Egg Allergy Trial, Cara In-Licenses Platform

Gadavist, also known as Gadovist and Gadovist 1.0 in other regions, is the US brand name of the aqueous 1.0M solution of gadobutrol, a gadolinium (Gd)-based extracellular contrast agent for MRI with a macrocyclic structure, disclosed the company.

Bayer wins US FDA approval for Gadato to assess myocardial perfusion and late gadolinium enhancement in adult patients with CAD

Initially, Nimble Therapeutics will leverage the speed and flexibility of its proprietary chemical synthesis platform, developed at Roche, to accelerate the discovery and optimization of macrocyclic peptidomimetics as novel therapeutics.

Nimble Therapeutics Spins Out from Roche to Commercialize Novel Drug Discovery Technology with Financing from Telegraph Hill Partners

According to their chemical structure, Gd-based contrast agents are subdivided into ionic and nonionic, macrocyclic and linear contrast agents (see Table 1).

The Gadolinium Controversy--An Update

(40) There are two structural classes of Gd chelate complexes: macrocyclic and linear.

[Gd.sub.n.sup.3+]@CNTs-PEG versus Gadovist[R]: In Vitro Assay

Macrocyclic lactones (ML) are the most widely used deparasitizing treatment in cattle for control of endo--and ectoparasites (Rodriguez-Vivas et al., 2010; Davey, Pound, Miller, & Klavons, 2010).

Onthophagus landolti y Canthon indigaceus chevrolati (Coleoptera: Scarabaeinae) son atraidos por las heces de ganado tratado con ivermectina en el tropico mexicano

The majority of the OPs, N-methyl carbamates, neonicotinoids, insect growth regulators, urea growth regulators, macrocyclic lactones, synergists, and organosulfites were registered for agricultural uses during the study.

Longitudinal, Seasonal, and Occupational Trends of Multiple Pesticides in House Dust

Firdaus, Template synthesis and spectroscopic characterization of 16-membered [N4] Schiff-base macrocyclic complexes of Co(II), Ni(II), Cu(II), and Zn(II): in vitro DNA-binding studies, J.

Synthesis, Characterization and Biological Screening of Ni(II), Co(II) and Cu(II) Complexes with Schiff Base Ligand: N,N'-Bis[1-(4-chlorophenyl)ethylidene]ethane-1,2-diamine

Within the collaboration, Cyclenium will perform synthetic and medicinal chemistry activities to generate and optimize new macrocyclic molecules effective against specific anti- infective targets chosen by AiCuris.

AICURIS AND CYCLENIUM DEVELOP NOVEL ANTI-INFECTIVES

The need to evaluate alternative approaches is emphasized by the evolving susceptibility of Dirofilaria immitis larvae to heartworm preventatives containing macrocyclic lactones, such as ivermectin.