The boy was first treated three years earlier by his family physician for "tiredness." According to the report, the then-14 year old was a picky eater but was "otherwise well and took no medications." Early testing showed he had low levels of vitamin B12 and macrocytic anaemia
, which were treated with B12 shots and "dietary advice." By 15, the boy's hearing began failing, and then the vision complications arrived.
Tests revealed he had low vitamin B12 levels and macrocytic anaemia
- a condition bringing larger-than-normal red blood cells.
 8(11.94%) patients had microcytic hypochromic anaemia, 1 (1.49%) had macrocytic anaemia
and there were 2 cases of sickle cell anaemia.
PHZ treated animals showed reductions in the levels of RBC and Hb, while MCV and MCHC increased significantly, resulting in macrocytic anaemia
. There was also a slight increase in MCH, which supports the induction of macrocytic anaemia
Microcytic, normocytic and macrocytic anaemia
were found in 32.1%, 57.5% and 10.4% of patients, respectively.
Folate deficiency will account for macrocytic anaemia
whilst vitamin A deficiency will decrease Hb concentration.
Microcytic hypochromic anaemia was found in 37% while 14% had macrocytic anaemia
. More than one etiology of anaemia was present in 19/100 (19%) patients.
No women of child-bearing age (n = 232) were found to have inadequate or low folate stores that would be associated with macrocytic anaemia
. No individual relationships between anaemia and parasitic infections including Toxoplasmosis, Trichinella, Toxocara, Echinococcus and H.
Intractable epilepsy as the presentation of vitamin B12 deficiency in the absence of macrocytic anaemia
. Epilepsia 2005; 46: 1147-8.
Looking at this discrepant data the current research was aimed to determine the prevalence of PA in patients with macrocytic anaemia
(high mean corpuscular volume [MCV]) and in patients with low serum B12 visiting the King Khalid University Hospital (KKUH) in Riyadh.
Signs and symptoms of vitamin B12 deficiency appear between the age of 4 and 12 months and include macrocytic anaemia
, weakness, fatigue, failure to thrive, and irritability.
The mean HbA1c level and proposed reference ranges for the five anaemia subgroups (anaemia of chronic disease [ACD], iron deficiency anaemia [IDA], mixed anaemia, macrocytic anaemia
and sickle-cell disease) are shown in table 2.