macroglobulin


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mac·ro·glob·u·lin

 (măk′rō-glŏb′yə-lĭn)
n.
A plasma globulin of high molecular weight.

macroglobulin

(ˌmækrəʊˈɡlɒbjʊlɪn)
n
1. (Biochemistry) an immunoglobulin of unusually high relative molecular mass, observed in the blood in some diseases
2. (Biochemistry) Also called: immunoglobulin M the normal form of this immunoglobulin
References in periodicals archive ?
In the specific case of our patient, the preexistent cirrhosis would probably have set a high value of the alpha 2 macroglobulin, the major component of the alpha electrophoretic band.
The following procedures were routinely performed before and after chemotherapy: physical examination, measurement of serum creatinine, C-reactive protein, serum lactate dehydrogenase, beta-2 macroglobulin, albumin levels, bone marrow aspirates and biopsy, and urinary globulin electrophoresis and immunofixation.
Studies have proven that human blood plasma and leukocytes contain 12-22% and 3% of zinc respectively.1 In serum there is 100 mg of zinc per deciliter which is bound to the a-2 macroglobulin and some loosely bounded with the albumin.1 The mechanism of zinc transfer into the plasma is still unknown, but Cotzias proposed it as a homeostatic mechanism by which it is distributed in various cells organelles within the body.2 Zinc also influences the process of bone mineralization and osteoclastic activity.
It also contains [TGF.sup.-B1], lysozyme and alpha-2 macroglobulin, which have anti-proteinase properties (Brooks, 2002).
The primary antibodies used were all obtained from Abcam (USA) and diluted as follows: anti-apolipoprotein A1 (Apo A1) goat polyclonal antibody (1:3000), anti-serum amyloid P (SAP) rabbit monoclonal antibody (1:3000), anti-kallistatin rabbit polyclonal antibody (1:3000), anti-complement factor H-related protein 1 (CFHL1) rabbit polyclonal antibody (1:3000), anti-carbonic anhydrase 1 (CA-1) rabbit monoclonal antibody (1:5000), anti-apolipoprotein L1 (Apo L1) rabbit polyclonal antibody (1:1500), and anti-alpha 2 macroglobulin (A2M) mouse monoclonal antibody (1:2000).
Some of Affinity Biologicals Inc.'s polyclonal antibodies include Plasminogen, Prothrombin, ATIII, PAI-1, Kininogen, Protein C, Protein S, Vimentin and Alpha 2- Macroglobulin. Apart from maintaining a wide variety of polyclonal antibodies, Affinity Biologicals offers a number of options in terms of concentration and the hosts, which means more than often, customers can find what they are specifically looking for.
Other methods that are used for the diagnosis of PROM include the measurement of vaginal D-amino oxidase, prolactin, alpha fetoprotein, insulin -like growth factor binding protein- 1, human gonadotropin, fetal fibronectin, placental alpha macroglobulin 1, urea, creatinine, and thyroid hormones.
These results show that level of apolipoprotein B, alpha-2- macroglobulin, ceruloplasmin, immunoglobulin heavy chain and 17 kDa proteins and expression of 23.5 kDa protein fractions are strong predictor of RHD and can be used for its diagnosis.
Most circulating PSA bind to alpha-1 antichymotripsin (ACT) and alpha-2 macroglobulin (AMG), while the remainder is free in the serum.[sup.28] In normal prostatic acini, PSA is processed by enzymatic nicking of a 7 kD segment, followed by back diffusion into the serum.