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Related to macroglobulinemia: Waldenstrom's macroglobulinemia


A condition marked by an abnormally high concentration of macroglobulins in the blood serum.
References in periodicals archive ?
The 52-year-old former Diamonds star and assistant manager, affectionately known as "Lumber" by the Broomfield fans, has been diagnosed with a form of cancer known as waldenstrom macroglobulinemia.
M2 EQUITYBITES-December 7, 2017-Janssen's Phase three iNNOVATE study indicates improved progression-free survival in Waldenstrom macroglobulinemia patients
M2 PHARMA-December 7, 2017-Janssen's Phase three iNNOVATE study indicates improved progression-free survival in Waldenstrom macroglobulinemia patients
In July 2017, Sunesis announced that the first patient was dosed at the Dana-Farber Cancer Institute in the Phase 1b/2 dose-escalation and cohort-expansion study evaluating the safety, pharmacokinetics, pharmacodynamics, and antitumor activity of its potent, reversible, non-covalent BTK-inhibitor, SNS-062, in adults with CLL, small lymphocytic leukemia, Waldenstroms macroglobulinemia, and mantle cell lymphoma.
On day 3 after his Mohs procedure, one 73-year-old man taking ibrutinib for Waldenstrom macroglobulinemia developed extensive bilateral periorbital ecchymosis that extended down to his upper chest.
CD5, CD10, and CD23 expression in Waldenstrom's macroglobulinemia.
The International Waldenstrom's Macroglobulinemia Foundation
Plasma cell dyscrasias, characterized by the monoclonal growth of plasma cells, include multiple myeloma, Waldenstrom macroglobulinemia (WM), monoclonal gammopathy of undetermined significance (MGUS), and amyloidosis.
Ibrutinib was approved by the Federal Drug Agency for treatment of B cell malignancies including CLL, mantle cell lymphoma, multiple myeloma, diffuse large B cell lymphoma, and Waldenstrom's macroglobulinemia between 2013 and 2015.
In studies examining genetic structures of families with CLL, it was found that the members of these families had many other lymphoproliferative disorders (Hodgkin and non-Hodgkin lymphoma, Waldenstrom macroglobulinemia, MBL) in addition to CLL (4).
1 The sign is typical but nonspecific as it has also been described in several other conditions like, Waldenstorm's macroglobulinemia, angioimmunoblastic T-cell lymphoma, drug-induced erythroderma, mycosis fungoides, acanthosis nigricans, discoid lupus erythematosus, acute contact dermatitis and large plaque parapsoriasis.
Multiple myeloma and Waldenstrom macroglobulinemia (discussed here), as well as leukemia, and other hematologic malignancies, can cause dyspnea or dyspnea on exertion through anemia, increasing blood viscosity, or direct lung involvement.