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(Biology) biology an abnormally great change in the characteristics of a population of animals or plants over relatively few successive generations: hypothesized in the evolutionary theory of punctuated equilibrium, which states that such populations remain stable for long periods of time and evolve into new species through sudden, drastic mutations
[C20: from macro- + mutation]
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014


(ˌmæk roʊ myuˈteɪ ʃən)

a mutation that results in a profound change in an organism, as a change in a regulatory gene that controls the expression of many structural genes.
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
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(8) [GA.sup.+] is population-based genetic algorithm that uses hydrophobic-core directed macromutation operator and random-walk-based stagnation recovery technique in addition to the regular GA operators.
Everyone agreed that Darwin's process could explain changes to the left of this point (microevolution), but some now argued that a fundamentally new phenomenon called genetic mutation or macromutation was responsible for the larger-scale differences to the right (macroevolution).
A macromutation in Tripsacum dactyloides (Poaceae): Consequences for seed size, germination, and seedling establishment.
An argument for nonasymptotic increases in fitness, however, must necessarily invoke some sort of macromutation, or beneficial mutation of large effect, that bridges an adaptive valley.
It was suggested that the highly significant effect of the macromutation Es1 probably reduced the power for identifying other QTL affecting stearic acid levels (Perez-Vich et al., 2002a).
We found no evidence to support the most extreme hypothesis that a single locus is responsible for the major differences between HV and HS in host use patterns; that is, there is no macromutation that might have caused a complete shift from a generalized to a specialized diet.