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(Biology) biology an abnormally great change in the characteristics of a population of animals or plants over relatively few successive generations: hypothesized in the evolutionary theory of punctuated equilibrium, which states that such populations remain stable for long periods of time and evolve into new species through sudden, drastic mutations
[C20: from macro- + mutation]
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
mac•ro•mu•ta•tion(ˌmæk roʊ myuˈteɪ ʃən)
a mutation that results in a profound change in an organism, as a change in a regulatory gene that controls the expression of many structural genes.
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