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n. macrosomia, cuerpo de un tamaño grande anormal.
English-Spanish Medical Dictionary © Farlex 2012
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[3] GDM is associated with maternal (pre-eclampsia, increase in caesarean deliveries, birth trauma), fetal (macrosomia, hypoglycaemia, shoulder dystocia) and perinatal (respiratory distress syndrome, jaundice, metabolic derangements) complications, while mothers and their offspring are at risk of developing obesity, T2D and other metabolic conditions later in life.
The medical term for this is macrosomia, which means "large body".
Gestational diabetes mellitus (GDM) is one of the most common complications of pregnancy and the incidence of GDM is increasing globally.1,2 Women with GDM are associated with many maternal (preeclampsia, cesarean section, birth injuries) and fetal consequences (macrosomia, hypoglycemia, shoulder dystocia).3,4 Commonly, GDM can be diagnosed by using the oral glucose tolerance test (OGTT) during 24-28 weeks of gestation.
When maternal diabetes develops in the latter half of pregnancy, it is associated with fetal macrosomia, cardiomyopathy, increased incidence of perinatal complications and mortality.
Gestational weight gain above the amount recommended by IOM guidelines was significantly associated with adverse outcomes in neonates, including macrosomia (adjusted odds ratio, 2.66), shoulder dystocia (aOR, 1.74), and neonatal hypoglycemia (aOR, 1.60).
About 14-46% of those receiving metformin require additional insulin for glycemic control and to minimize the frequency of macrosomia and its associated risks to the infant8,9.
Obese women suffered more complications such as gestational diabetes, gestational hypertension, pre-eclampsia, macrosomia, antepartum haemorrhage, etc.
In addition, neonatal information was collected including birth weight, Apgar scores (at 1, 5, and 10 min postdelivery), neonatal care unit admission, hypoglycemia, hyperbilirubinemia, RDS, macrosomia, congenital malformations, and neonatal death.
However, heterozygous HNF4A mutations have a Janus effect on glucose metabolism, which leads to either macrosomia and hyperinsulinemic hypoglycemia during infancy or MODY Type in adulthood (6).
Las variables para el perfil perinatal fueron: sexo, edad gestacional, puntuacion del test Apgar al minuto y a los 5 minutos de nacer y peso tomandose como variable cuantitativa y cualitativa categorizandose en muy bajo peso (<1.500 gramos (g) (8)), bajo peso (<2.500 g (8)); normopeso (2.500-3.999 g) y macrosomia (>4.000 g).
The researchers found that the frequency of the primary outcome of a composite criterion, including macrosomia, neonatal hypoglycemia, and hyperbilirubinemia, was 27.6 and 23.4 percent in the glyburide and insulin groups, respectively (difference, 4.2 percent; one-sided 97.5 percent confidence interval, −∞ to 10.5 percent; P = 0.19).
Macrosomia raises the risk that an infant will experience bone fracture during delivery.