major histocompatibility complex


Also found in: Thesaurus, Medical, Acronyms, Encyclopedia, Wikipedia.
Related to major histocompatibility complex: human leukocyte antigen

major histocompatibility complex

n. Abbr. MHC
A group of genes in humans and most other vertebrates that code for cell-surface glycoproteins (called MHC molecules) which function in the immune system and also are principally responsible for determining tissue compatibility in transplants.

major histocompatibility complex

n
(Genetics) the full name for MHC

MHC

major histocompatibility complex: a group of genes that determine histocompatibility antigens, located in humans on the sixth chromosome. Compare HLA.
Translations
complexe majeur d’histocompatibilité
References in periodicals archive ?
The revealed differences in the content of soluble molecules of the major histocompatibility complex in COPD patients depending on the severity degree and the disease period allow us to consider these proteins as potential biomarkers of activation of local and systemic inflammation and severity of COPD.
The antigens of the HLA system are determined by genes present in the major histocompatibility complex which is located on the short arm at the 6th chromosome (6p21.3) in humans and extends over some 4 centimorgans of DNA, about 4 x[10.sup.6] base pair.
Kretsovali, "Acetylation by PCAF enhances CIITA nuclear accumulation and transactivation of major histocompatibility complex class II genes," Molecular and Cellular Biology, vol.
Abbreviations Ab: Antibody ABOi: ABO-incompatible AECA: Autogenous anti-endothelial cell antibody AMR: Antibody-mediated rejection APC: Antigen presenting cell A[T.sub.1]R: Angiotensin type 1 receptor AVA: Anti-vimentin antibodies CMR: Cell-mediated rejection DSA: Donor-specific antibody EDIL3: EGF-like repeats and discoidin I-like domain 3 EMT: Endothelial-to-mesenchymal transition E[T.sub.A]R: Endothelin-1 type A receptor HLA: Human leukocyte antigen FLT3: Fms-like tyrosine kinase 3 ICAM4: Intercellular adhesion molecule 4 LG: Laminin-like globular domain MICA: Major histocompatibility complex class I related chain A antigen Treg: Regulatory T-cell.
In humans, major histocompatibility complex controlled by the genes located on chromosome 6 is responsible for ensuring compatibility between donors and recipients.
Cathepsin S is involved in the assembly of the major histocompatibility complex II protein, and by interfering with this process, the effector T-helper cell response may be muted and T-cell interaction with B cells may be decreased.
(2) One of these risk genes, on chromosome 6, is in the major histocompatibility complex and has the strongest association with schizophrenia (P = [10.sup.-31]).
Comparative organization and function of the major histocompatibility complex of domesticated cattle.
Called the major histocompatibility complex, or MHC, this DNA chunk carries information used by the immune system to help identify invaders.
Specialized cells in the thymus interact with a molecule known as the Major Histocompatibility Complex class II (MHCII) to "teach" T cells to differentiate between normal tissues and organs, and foreign invaders.
PLX cells, and other MSC, affected complex pathways in order to prevent the priming of Type 1 T helper cell (Th1) responses towards major histocompatibility complex mismatches.

Full browser ?