ISLAMABAD -- Vitamin A may protect children against the mosquitoborne malaria parasite
, a study said.
Mosquitoes become infected with the malaria parasite
when they bite an infected person.
5, 2014 /PRNewswire-USNewswire/ -- An international research collaborative has determined that a promising anti-malarial compound tricks the immune system to rapidly destroy red blood cells infected with the malaria parasite
but leave healthy cells unharmed.
Working in Uganda, one of the most malaria-plagued nations in Africa and one in which individuals are repeatedly exposed to the malaria parasite
, UCSF scientists found that a depletion of immune cells known as gamma delta T cells diminishes inflammatory responses in infected children responses that when unabated can become debilitating or deadly.
While some patients became sick, others were protected by naturally occurring antibodies that stopped the malaria parasite
from penetrating their red blood cells during the blood stage of the disease, which produces severe symptoms such as fever and anaemia.
The heat-seeking detector, which is coupled to an infrared imaging microscope, allowed the team to detect the earliest stages of the malaria parasite
in a single red blood cell, while infrared signature from the fatty acids of the parasites enabled the scientists to detect the parasite at an earlier stage, and crucially determine the number of parasites in a blood smear.
AN Achilles' heel in the malaria parasite
has been identified that could be targeted to stop the organism spreading and multiplying.
The first complete genome sequences of the human malaria parasite
Plasmodium falciparum was published in 2002, and in the decade since, genome-scale data sets from more species of Plasmodium and related organisms have been deposited in public databases.
so that it would make proteins that target the malaria parasite
at the most vulnerable stage of its life cycle -- when it hides in the gut of the mosquito.
Snug inside a human red blood cell, the malaria parasite
hides from the immune system and fuels its growth by digesting hemoglobin, the cell's main protein.
THE malaria parasite
can ensure it keeps a host body to itself by preventing further malarial infections, according to researchers.
Chemical compounds used by seaweed found in waters off the Fiji islands, to ward off fungal attacks, have shown promising activity against the malaria parasite