mast cell


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mast cell

n.
A cell produced in bone marrow that functions in allergic reactions and other inflammatory and immune responses by releasing substances such as histamine and cytokines and by directly killing pathogens. Mast cells are found chiefly in connective tissue and contain basophilic granules.

[Partial translation of German Mastzelle, well-fed cell (from an early view that the granules were from phagocytosis) : Mast, food, mast (from Middle High German, from Old High German) + Zelle, cell.]

mast cell

n
(Biology) a type of granular basophil cell in connective tissue that releases heparin, histamine, and serotonin during inflammation and allergic reactions
[C19: from mast2, on the model of German Mastzelle]

mast′ cell`


n.
a large granular cell, common in connective tissue, that produces heparin, histamine, and serotonin.
[1885–90; partial translation of German Mastzelle=Mast mast2 + Zelle cell]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.mast cell - a large connective tissue cell that contains histamine and heparin and serotonin which are released in allergic reactions or in response to injury or inflammation
connective tissue - tissue of mesodermal origin consisting of e.g. collagen fibroblasts and fatty cells; supports organs and fills spaces between them and forms tendons and ligaments
somatic cell, vegetative cell - any of the cells of a plant or animal except the reproductive cells; a cell that does not participate in the production of gametes; "somatic cells are produced from preexisting cells";
References in periodicals archive ?
Church, "Human mast cell heterogeneity: histamine release from mast cells dispersed from skin, lung, adenoids, tonsils, and colon in response to IgE-dependent and nonimmunologic stimuli," The Journal of Allergy and Clinical Immunology, vol.
Our study revealed that mast cell count is increased in OLP compared to OLR thereby guiding us to propose that mast cell count can be used as one of the essential histopathological elements in the differentiation of OLP and OLR.
To confirm that the protective effects of mast cell engraftment were not a result of supplying IL10 derived from engrafted WT BMMCs, we also assessed colitis in DKO mice engrafted with [IL10.sup.-/-] BMMCs (derived from [IL10.sup.-/-] mice).
This is especially true with mast cell tumors, which can be found within lipomas (a mast cell is an immune cell found in connective tissue; see sidebar).
Similarly, canine mast cell tumor is the most common neoplasm, representing 7 to 25% and 11 to 27% of all skin tumors and malignant skin tumors in dogs (Bostocket al., 1973).
(the 'Company') (Nasdaq: ALLK), a biotechnology company developing AK002 for the treatment of eosinophil and mast cell related diseases, today reported financial results for the second quarter ended June 30, 2019.
Treatment focuses on minimizing mast cell degranulation
Raj Patel, MD, and Thalia Farshchian, ND, of Medical Options for Wellness (MOW; http://medicaloptionsforwellness.net) in Foster City, California, have observed clinically how important it has become to evaluate their patients for mast cell activation syndrome (MCAS).
Avapritinib has received FDA Breakthrough Therapy Designation for the treatment of patients with advanced SM, including the subtypes of aggressive SM, SM with an associated hematologic neoplasm and mast cell leukemia.
Those of you who have a pet who has had surgery to remove mammary tumours, mast cell tumours or any other type of lump or bump that is excess to requirements will know exactly what I mean.
In the present study, we showed that compound 48/80 induced dural mast cell degranulation leads to vasodilation of middle meningeal artery and its anterior and posterior branches.