Chronic nicotine administration elevated HINT1 expression in mouse NAc, which could then be reversed by a nicotine antagonist, mecamylamine
, after 24 hours or drug withdrawal after 72 hours .
Different concentrations of chemokines CCL3, CCL4, CCL5, or CXCL16 (R&D Systems; 0.1-50 ng/ml) were applied together with BzATP, in the presence or absence of antagonists mecamylamine
hydrochloride (100 [micro]M; Sigma-Aldrich), [alpha]-bungarotoxin (1 [micro]M; Tocris Bioscience, Bristol, UK), and strychnine hydrochloride (10 [micro]M; Sigma-Aldrich) or of the conotoxins ArIB [V11L, V16D] (500 nM) or RgIA4 (200nM) [16-19].
The antinociceptive effect elicited by this extract in the glutamate test was significantly attenuated by intraperitoneal (i.p.) treatment of mice with atropine, mecamylamine
, or Larginine but not with naloxone or D-arginine , thus supporting the involvement of the cholinergic system and of the L-arginine-nitric oxide pathway.
attenuates ephedrine-induced hyperactivity in rats," Pharmacology Biochemistry & Behavior, vol.
Other medications tested included atomoxetine, citalopram, dextromethorphan, levetiracetam, mecamylamine
, omega-3 fatty acid, and secretin.
Cholinergic receptor blockade by scopolamine and mecamylamine
exacerbates global cerebral ischemia induced memory dysfunction in C57BL/6 J mice.
This reduction in body weight was in agreement with that reported by study22 that showed that blocking nicotinic receptor by mecamylamine
a nonselective nicotinic acetylcholine receptor antagonist present in brainstem would promote food intake by blocking dopaminergic pathway.
Pharmaceutical company Retrophin (NasdaqGM:RTRX) said on Tuesday that it has agreed to sell its non-core assets ketamine, Syntocinon Nasal Spray (oxytocin) and Vecamyl (mecamylamine
HCI tablets) for a USD3m upfront payment to Turing Pharmaceuticals.
: This nicotine antagonistic agent blocks the rewarding effect of nicotine.
Its product offering includes Chenoda, a chenodeoxycholic acid used for the treatment of patient suffering from gallstones and cerebrotendinous xanthomatosis (CTX), and Vecamyl, or mecamylamine
tablets, for management of moderately severe to severe essential hypertension.
Biala, "A comparison of mecamylamine
and bupropion effects on memory-related responses induced by nicotine and scopolamine in the novel object recognition test in mice," Pharmacological Reports, vol.