mechanism of action


Also found in: Thesaurus, Medical, Acronyms, Encyclopedia, Wikipedia.

mech´an`ism of ac´tion


n.1.(Medicine, Biochemistry) The mechanism{2} by which a pharmacologically active substance produces an effect on a living organism or in a biochemical system; as, the mechanism of action of actinomycin involves its binding to DNA. The mechanism of action is usually considered to include an identification of the specific molecular targets to which a pharmacologically active substance binds or whose biochemical action it influences; a general recognition of the broad biochemical pathways (such as DNA synthesis, protein synthesis, cholesterol synthesis) which are inhibited or affected by a substance is termed its mode of action.
References in periodicals archive ?
Chahal, 'we have been able to show that through an anti-inflammatory mechanism of action, such patients have an improvement in pain, function and quality of life.
User's guide to mechanism of action and clinical use of GLP-1 receptor agonists.
The delivery and the mechanism of action are being worked out at present.
Mark Hammond, Intertek Pharmaceutical Services business leader, said, "Our expanded GLP Bioanalytical Centre of Excellence in San Diego and new technologies provide a broader range of bioanalytical, biomarker, and cell-based capabilities services to meet our clients' needs in preclinical and clinical bioanalysis, helping them to understand the safety, efficacy and mechanism of action of their small and large molecule drugs in development."
DelveInsight's released Oncology based Mechanism of Action (MOA) reports provides the targets-mode of action based information-across all the therapy under research work, pipeline products across all the companies, current technology, molecule type, stage, company finances, comparative analysis and therapeutic assessment at every step.
The meeting, which was chaired by head of the restructuring team Staff Brigadier Nasser Ali al-Harbi, discussed the plan and the mechanism of action required to complete the tasks and actions relating to the restructuring of the armed forces.
A great diversity of mechanisms is associated with the analgesic effect of these monoterpenes, varying from opioid agonists to nitric oxide (NO) synthesis modulators, with many monoterpenes demonstrating more than one mechanism of action. Linalool, for example, is able to modulate about ten disparate systems.
The antidepressant effects and mechanism of action of total saponins from the caudexes and leaves of Panax notoginseng in animal models of depression.
Their study is the first analysis of pesticides classified by presumed mechanism of action rather than by intended use or chemical class.
I question the statement, in this supplement to OBG MANAGEMENT, that the mechanism of action of intrauterine contraceptives is spermicidal.
In vitro studies have shown that quercetin inhibits the replication of a number of different viruses, an effect that might explain its mechanism of action in preventing respiratory infections.
About MBP8298 - Novel Mechanism of Action In MS patients, the body's immune system inappropriately attacks the myelin coating around the nerves in the brain and spinal column, whereas healthy people are otherwise "tolerant" of such common body components.