Smith is suing the government and a drug manufacturer (Hoffman-LaRoche) over the use and side effects of the anti-malarial drug mefloquine
, a "drug of last resort," which caused hallucinations and other effects (the CAR's Somali peacekeeping mission brought the questionable use of this drug to the fore).
In addition, increased pfmdr1 copies have been associated with resistance to mefloquine
(in vivo, in vitro, or both) and partially to lumefantrine (13-18).
She links her husband's aggressive behaviour in Somalia to the anti-malaria drug mefloquine
While quinine was isolated from the bark of the cinchona tree in 1820, chloroquine, proguanil, mefloquine
, and atovaquone each were developed during or after a military conflict during 1945-1985.
Drugs for chloroquine-resistant malaria are quinine, sulfadoxine-pyrimethamine combination, mefloquine
, artesunate and its derivatives, halfantrine and certain antibiotics.
In the 2001 WHO strategy (5) for retarding development of resistance to anti-malarial drugs, the fixed-dose combination of Artesunate (AS) + Mefloquine
(MQ) was assessed as being the most appropriate for Latin America and Asia.
Currently, treatment for malaria combines rapidly-acting artemisinins with lumefantrine, amodiaquine, mefloquine
and other antimalarials for durability.
20) These HPLC methods were used to characterize the pharmacokinetic-pharmacodynamic interaction of mefloquine
in resistant P falciparum malaria on the Thai-Burma/Myanmar ** border, (21) assess the efficacy of halofantrine in treating Thai patients who failed mefloquine
chemoprophylaxis, (22) evaluate the potential of ciprofloxacin in treating drug-resistant falciparum malaria, (23) assess the effect of food on the disposition of halofantrine in treating falciparum malaria (24) and determine the effectiveness of high-dose mefloquine
in treating multidrugresistant falciparum malaria.
is a quinoline methanol compound which is effective against the asexual blood stages of Plasmodium falciparum.
, halofantrine and quinine .
Relatively moderate risk: Medications used to treat viral or bacterial infections, such as flunarizine, mefloquine
for malaria, efavirenz (Sustiva) for HIV and acyclovir for shingles; and cholesterol-lowering statin drugs.
When artemisinin was modified to artesunate or artemether its bioavailability improved and it was used in conjunction with other antimalarial drugs, most commonly mefloquine
, to treat malaria.