of vitamin C prevent the development of tolerance and physical dependence on morphine in mice.
Many OTC supplements contain biotin megadoses
, up to 10 mg per pill, which is more than 300 times the recommended daily intake.
The most striking of these findings are the significantly increased risks of falls and fractures associated with vitamin D megadoses
, said Dr.
You should use supplements intelligently, following recommended daily allowances and avoiding megadoses
The only medical evidence in support of megadoses
of biotin (up to 300 mg per day, 10000 times the DRI) applies to patients with secondary progressive multiple sclerosis, in whom clinical symptoms and quality of life have been improved by using biotin as a complementary medicine.
A: Overall, trials that tested megadoses
of the antioxidant vitamins beta-carotene, vitamin C, and vitamin E didn't show a reduced risk of heart disease, stroke, cancer, diabetes, or other health problems.
More than 20 years ago, evidence was provided that megadoses
of vitamin C diminish body stores of cysteine, a sulfur containing amino acid, which is involved in detoxifying cyanide to thiocyanate (Basu 1983; Calabrese 1979).
High doses did boost vitamin D levels in participants who had previously been deficient, but no improvement was seen in their leg function--in fact, vitamin D megadoses
were associated with an increased number of falls.
It is also believed that megadoses
of nonenzymatic antioxidants (e.
Current studies, limited to mice or lab dishes, often analyze megadoses
of particles far beyond what any normal diet would include.
should never be prescribed in absence of documented vitamin D deficiency.
Neste, proliferam as dietas sem gluten (63,64), as megadoses
de vitamina D (65), o tratamento em camaras hiperbaricas (66), o neurofeedback (67), os enemas (68), as saunas de infravermelho e os bloqueadores da sintese da testosterona (69).