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 (mĕg′ə-kăr′ē-ō-sīt′, -ə-sīt′)
A large cell of the bone marrow that has a lobulated nucleus and releases platelets into the bloodstream.


(Physiology) an abnormally large bone marrow cell, with a lobulated nucleus, that produces platelets through the fragmentation of its cytoplasm


(ˌmɛg əˈkær i əˌsaɪt)

a large bone marrow cell, with a lobed nucleus, whose cytoplasm is the source of blood platelets.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.megakaryocyte - a large bone marrow cellmegakaryocyte - a large bone marrow cell; regarded as the source of blood platelets
bone cell - a cell that is part of a bone
References in periodicals archive ?
Ebert is the primary researcher studying Interaction of RUNX1 and the cohesin complex in megakaryocyte development and myeloid disease.
Studies have shown that alkylating agents affect pluripotent stem cells, cyclophosphamide affect megakaryocyte progenitors.
It's thought that in our bodies every single megakaryocyte produces like a thousand platelets, and when you do it in culture [outside the body] it's like 10," he said.
Megakaryocyte biology and the production of platelets.
Some data also suggest preferential expansion of the megakaryocyte cell lineage as a result of CALR's inability to export [Ca.
Prothrombotic megakaryocyte and platelet changes in hypertension are reversed following treatment: a pilot study.
The Bone marrow pictures in CML without treatment showing hypercellularity due to excessive proliferation of the granulocytes with myelocytes predominantly and presence of blast cells from <10% to >20% in the bone marrow and peripheral blood according to the world health organization criteria that divide the CML in to chronic, accelerated phases and blast crisis, there is decreased or normal or increased megekayrioposis as well as moderate to marked reticulin fibrosis with presence of small megakaryocyte containing hypolobulated nuclei, sea-blue histiocytes and gaucher cell and these changes are return to the normal state after treatment and the immunohisto-chemistry is used for differentiating the myeloblastic and lymphoblastic crisis of CML [7,8].
Immune thrombocytopenia (ITP) is an autoimmune disorder characterised by immunological destruction of platelets (primarily due to the production of platelet-reactive autoantibodies), along with an inability to compensate by increasing production of platelets as a result of immune-mediated megakaryocyte damage and dysfunction.
7 The cause is multifactorial due in part to increased sequestration in the spleen bone marrow suppression by HCV infection and by interferon treatment and reduced production of thrombopoietin (a cytokine that regulates megakaryocyte maturation and platelet production).
Myeloid recovery was defined as an absolute neutrophil count of more than 500/[micro]L, and erythroid and megakaryocyte lineage reconstitution were defined as reticulocyte counts of more than 3 x [10.