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 (mĕg′ə-kăr′ē-ō-sīt′, -ə-sīt′)
A large cell of the bone marrow that has a lobulated nucleus and releases platelets into the bloodstream.


(Physiology) an abnormally large bone marrow cell, with a lobulated nucleus, that produces platelets through the fragmentation of its cytoplasm


(ˌmɛg əˈkær i əˌsaɪt)

a large bone marrow cell, with a lobed nucleus, whose cytoplasm is the source of blood platelets.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.megakaryocyte - a large bone marrow cellmegakaryocyte - a large bone marrow cell; regarded as the source of blood platelets
bone cell - a cell that is part of a bone
References in periodicals archive ?
In this study, the scientists found that hematopoietic stem cells and neutrophils migration depends on the megakaryocyte size and distributions.
Bone Marrow Aspiration Smears (a) (b) (c) Hyperceliuiar Marrow with Depletion of AH Three Elements, i.e., Erythroid, Myeioid and Megakaryocyte. Majority Are Lymphoblasts of FAB L1 and L2 Morphology with Few of Them Showing Coarse Cytoplasmic Granules
Blood and bone marrow smear showed very little platelet and thrombacytogenous megakaryocyte, with normal numbers of megakaryocytes.
Mulpleta is an orally bioavailable, small molecule TPO receptor agonist that interacts with the transmembrane domain of human TPO receptors expressed on megakaryocytes to induce the proliferation and differentiation of megakaryocytic progenitor cells from hematopoietic stem cells and megakaryocyte maturation.
Immunophenotyping revealed 23% blast cells, positive for megakaryocyte markers (CD42b, CD41, CD61), myeloid markers (CD33), progenitor cell markers (CD117, CD34) and T cell marker--CD7 positive.
[16,18,19] In severe IDA, as megakaryocyte numbers decrease, megakaryocyte sizes increase.
Bone marrow examination showed normocellular marrow, and megakaryocyte number was within normal range with 12 (normal range: 10 to 50) number/[mm.sup.2].
Platelets are differentiated from megakaryocytes. One megakaryocyte can produce thousands of platelets [21].
The Enumeration of Megakaryocytes. Megakaryocyte quantity counting was performed according to the classical counting method.
Ebert is the primary researcher studying Interaction of RUNX1 and the cohesin complex in megakaryocyte development and myeloid disease.
"It's thought that in our bodies every single megakaryocyte produces like a thousand platelets, and when you do it in culture [outside the body] it's like 10," he said.
Considering the importance of megakaryocyte polyploidy in platelet generation, exploring the mechanism under megakaryocyte polyploidization became one of the hotspots in the field.