These cases predict more reticulin fibrosis, occasional megakaryocytic
clustering with atypia, and erythroid and megakaryocytic
Bone marrow aspirate revealed hypercellular marrow with marked depletion of all three elements, i.e., erythroid, myeloid and megakaryocytic
. 80% cells were blasts, morphologically similar to peripheral smear blasts with high nuclear to cytoplasmic ratio, scanty to moderate cytoplasm and inconspicuous nucleoli.
Lineage-specific markers, including myeloid (CD13, CD33, CD117, MPO), monocytic (CD11b, CD14, CD64), megakaryocytic
(CD61), B-cell (CD19, CD10, CD20) and T-cell (CD3) antigens, were negative.
(37,38,40) The presence of megakaryocytic
dysplasia may pose a diagnostic challenge to differentiation of thrombocytopenia in the setting of germline ANKRD26 mutation versus MDS.
Both the congenital syndromic SA patients showed megakaryocytic
hypoplasia and dysplasia of the myeloid and erythroid lines indicating a more generalized pathology.
Bone marrow examination (BME) showed hypocellularity in the myeloid and megakaryocytic
A diagnosis of AML can be made based on (1) [greater than or equal to]20% blasts of myeloid and/or monocytic or megakaryocytic
lineages and (2) the presence of recurrent cytogenetic abnormalities, including t(8;21) (q22;q22.1), inv16(p13.1q22), or t(16;16) (p13.1:q22) and PML-RARA fusion (1).
Mulpleta is an orally bioavailable, small molecule TPO receptor agonist that interacts with the transmembrane domain of human TPO receptors expressed on megakaryocytes to induce the proliferation and differentiation of megakaryocytic
progenitor cells from hematopoietic stem cells and megakaryocyte maturation.
(A serum methotrexate level below approximately 0.02 [micro]-Mol/L has been indicated as necessary for resumption of DNA synthesis.) A bone marrow biopsy revealed hypocellular bone marrow, with a marrow-tofat ratio of 20:80 and trilinear panhypoplasia of the erythroid, myeloid, and megakaryocytic
cell lines; no metastatic tumor or granuloma was seen.
Myeloproliferative disorders are characterized by purposeless proliferation of one or more of nonlymphoid marrow cell lines (granulocytic, monocytic, erythrocytic or megakaryocytic
) (Harvey, 2001).
Note granularity and mononuclearity of megakaryocytic
(B), binuclearity of erythroid precursors (C) and pseudo Pelger-Huet (D).
also showed that survivin is definitely required for megakaryocytic
and erythroid progenitors' development, although its expression diminishes in terminal stages of megakaryocytes' differentiation .