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Adj.1.Macrencephalic - having a large brain casemacrencephalic - having a large brain case    
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Megalencephalic leukoencephalopathy (MLC) is an uncommon neurodegenerative disorder characterized by infantile-onset megalencephaly and cerebral leukoencephalopathy, particularly subcortical cysts in the anterior temporal area of the brain.
Though Alexander disease, Canavan disease, and Glutaric aciduria have been considered as differential diagnosis of megalencephalic leukoencephalopathy with subcortical cysts, [9] these conditions are quite unlikely to have such a mild clinical course.
Certain leukodystrophies (megalencephalic leukodystrophy) have been shown to be common in the certain community and the founder mutation has also been identified previously.