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An abnormally large immature red blood cell (erythroblast) found especially in the blood of people with certain types of anemia and often associated with vitamin B12 deficiency.

meg′a·lo·blas′tic adj.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Adj.1.megaloblastic - of or relating to megaloblastsmegaloblastic - of or relating to megaloblasts  
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References in periodicals archive ?
The council's public health department also submitted a report highlighting the side effects of laughing gas including dizziness, nausea, megaloblastic anaemia and nerve damage.
Leucovorin Calcium is also used as a rescue drug after high-dose methotrexate therapy in osteosarcoma, in the treatment of megaloblastic anemia due to folic acid deficiency when oral therapy is not feasible, and in combination with 5-fluorouracil to prolong survival in the palliative treatment of patients with advanced colorectal cancer.
It has been found that incidence of megaloblastic anaemia is increasing over last two decades.
Heavy metal poisoning, haemoglobinopathies, severe infections, sideroblastic anaemia, megaloblastic anaemia.
KHAPZORY is not indicated for the treatment of pernicious anemia and megaloblastic anemia secondary to lack of vitamin B12 because of the risk of progression of neurologic manifestations despite hematologic remission.
Iron deficiency, haemolytic and megaloblastic anaemia occur in diabetes through various mechanisms.
Hyperhomocysteinemia May occur isolated, but is also a feature of inherited metabolic disorders, including homocystinuria, due to mutation in the CBS gene, and N(5,10)-methylenetetrahydrofolate reductase deficiency, caused by mutation in the MTHFR gene (607093); homocysteinemia/ homocystinuria and megaloblastic anemia can result from defects in vitamin B12 (cobalamin; cbl) metabolism.
Deficiency of these vitamins leads to megaloblastic anemia due to ineffective erythropoiesis.
Cheilitis may also be associated with numerous conditions or diseases, e.g., nutritional deficiencies, such as megaloblastic anemia due to vitamin B deficiency, anemia due to iron deficiency, oral candidiasis, diabetes (2,4-8).
Myelodysplastic morphology of blood cells can be encountered not only in myelodysplastic syndromes but also can be seen in non-clonal disorders, cause of which can be pointed to viral, bacterial, parasitic infections, autoimmune disorders, juvenile rheumatoid arthritis, immune thrombocytopenic purpura, iron deficiency anemia, megaloblastic anemia, dysgranulopietic neutropenia, congenital neutropenia, malignant lymphoma, after administration of granulocyte colony stimulating factor, chemotherapy, steroids, smoking, alcohol, posttransplantation, copper deficiency also, together with or without cytopenia.
The sections include acute lymphoblastic leukemia, chronic obstruction pulmonary disease, general anesthesia, growth retardation and hypogonadism, human immunodeficiency virus infection, megaloblastic anemia, peri-menopause and osteoporosis, primary adrenal deficiency (Addison's Disease), solid organ transplant, and diabetes mellitus.
(5, 9, 11, 12, 13) Folic acid is also important in the third trimester to help prevent megaloblastic anaemia.