megalocephaly


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meg·a·lo·ceph·a·ly

 (mĕg′ə-lō-sĕf′ə-lē)
n. pl. meg·a·lo·ceph·a·lies

meg′a·lo·ce·phal′ic (-sə-făl′ĭk), meg′a·lo·ceph′a·lous (-sĕf′ə-ləs) adj.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

megalocephaly

(ˌmɛɡələʊˈsɛfəlɪ)
n
(Pathology) another word for megacephaly
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.megalocephaly - an abnormally large headmegalocephaly - an abnormally large head; differs from hydrocephalus because there is no increased intracranial pressure and the overgrowth is symmetrical
abnormalcy, abnormality - an abnormal physical condition resulting from defective genes or developmental deficiencies
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
A direct deletion of FoxOs in neural precursor cells results in megalocephaly or enlarged brain, suggesting increased proliferation of NPCs that can result in the depletion of NPC pool in the adult brain [69].
Among the classic clinical findings of JS are hypotonia, ataxia, mental-motor retardation, and respiratory findings such as apnoea/hyperpopnoea, and opthalmological findings as ocular motor apraxia.1,5 In the patients with JS, some studies determined that the respective frequency of anomalies as tongue protusion, tongue tumours, polydactyly, kidney anomalies, megalocephaly, microcephaly, ocular coloboma, retinal dystrophy, esophageal reflux, pectus excavatum, hepatic anomalies, hydrocephaly, bradycardia, cardiac failure, cerebral palsy, asthma, webbed feet and cleft lip.3,4,6 As JS is an autosomal recessive transmitted disease, there is a risk to other children of a couple to be affected.
Abnormal chromatin structures and DNA strand breaks are correlated with severe forms of morphologically abnormal profiles, such as the combined presence of megalocephaly and multiple tails with disomy (72) or the incidence of globozoospermia accompanied by increased aneuploidy rates (30).