38] In individuals genetically susceptible to developing vitiligo, the trigger event results in melanocyte
dysfunction or death that, in turn, initiates an immune response which causes the spread of melanocyte
The etiology of vitiligo is still unknown but, genetic factors, oxidative stress, autoimmunity, neurological factors, toxic metabolites and lack of melanocyte
growth factors might contribute a precipitating factor in susceptible individuals.
Inhibitors of mammalian melanocyte
tyrosinase: in vitro comparisons of alkyl esters of gentisic acid with other putative inhibitors.
Pigmented eccrine poromas: expression of melanocyte
stimulating cytokines by tumor cells does not always result in melanocyte
Afamelanotide, a first-in-class investigational chemical analogue of alpha-melanocyte
-stimulating hormone, is a melanocortin-1 agonist that activates melanocytes
and increases melanin levels in the skin.
Emi Nishimura, Scott Granter and David Fisher, from the Dana-Farber Cancer Institute and Children's Hospital in Boston, determined that hair colouration is ultimately determined by the presence of melanocyte
stem cells in the hair follicle.
With age, there is a decline in melanocyte
activity and number.
Results of the first long-term study of autologous melanocyte
transplantation for pigment disorders, such as vitiligo and piebaldism, show that treatment benefits are sustained for some patients, according to researchers at the University of Uppsala in Sweden.
We assessed the effects of sublethal pulsed laser-light insult to a human melanocyte
cell line using a gene expression microarray for specific genes shown to be important in biological processes that could lead to cancer or cell death.
has many long, elaborately branched projections that extend among surrounding keratinocytes.
increases when hair is new and is lost altogether when hair falls out.
The accuracy and universality of Murray's rule hinges on his assertion that a single, size-dependent mechanism produces patterns of melanin-producing cells (melanocytes
) and "whether or not a melanocyte
produces melanin depends on the presence of a chemical.