Preclinical efficacy and safety has been demonstrated in numerous animal disease models including mucositis, colitis, macrophage activation syndrome (MAS) as well as bacterial infections, including
melioidosis.
The global aquafeed market is expected to grow at a considerable rate due to rising seafood consumption, increasing consumer concerns and regulatory pressure to maintain high quality of fishes to avoid any outbreak of diseases (salmonella, botulism,
melioidosis).
Under a cost-sharing contract, BARDA and VenatoRx will share the costs of all studies needed to bring the drug to market, including planned pivotal Phase 3 clinical trials to treat cUTI, hospital-acquired and ventilator-associated bacterial pneumonia, carbapenem-resistant pathogens and a data package to potentially support the use of cefepime/VNRX-5133 in the treatment of
melioidosis and glanders.
Threats of bioterrorism and the ease of global travel have led nations to also be concerned about diseases such as tularemia, plague, and
melioidosis (1).
pseudomallei, therefore serological differentiation between
melioidosis and glanders through reference complement fixation test (CFT) is not possible particularly in the regions endemic with
melioidosis (Naureen et al., 2007; Kumar et al., 2011; Singha et al., 2014; Ghori et al., 2017).
Melioidosis, an emerging underdiagnosed infectious disease is caused by Burkholderia pseudomallei, a Gram negative bacillus commonly found in the soil of tropical countries.
Categories Diseases/Agents A Anthrax (Bacillus anthracis), Botulism (Clostridium botulinum), Plague (Yersinia pestis), Smallpox (Variola major), Tularemia (Francisella tularensis), Viral hemorrhagic fevers B Brucellosis (Brucella species), epsilon toxin of Clostridium perfringens, food safety threats (e.g., Salmonella species, Escherichia coli O157:H7, Shigella), Glanders (Burkholderia mallei),
melioidosis (Burkholderia pseudomallei), Psittacosis (Chlamydia psittaci), Q fever (Coxiella burnetii), ricin toxin from Ricinus communis (castor beans),Staphylococcal enterotoxin B, Typhus fever (Rickettsia prowazekii), viral encephalitis [alphaviruses (e.g.
Mantoux test revealed a wheal of 12 mm and the serology and cultures for
melioidosis were negative.
This specimen was sent to a commercial laboratory in New Jersey, which identified Burkholderia pseudomallei, the causative organism of
melioidosis, on August 30.
He dictated most of the stories from a sickbed, since he had come down with an obscure East Asian bacterial disease,
melioidosis.
Kunnathuparambil et al (10) described
melioidosis in a 47 year old male who was treated as case of splenic tuberculosis based on splenic lesions on imaging and fever.