mercaptopurine


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mer·cap·to·pu·rine

 (mər-kăp′tō-pyo͝or′ēn)
n.
A purine analog, C5H4N4S, that interferes with the synthesis of purines and is used primarily in the treatment of certain forms of leukemia.

mercaptopurine

(məˌkæptəʊˈpjʊəriːn)
n
(Pharmacology) a drug used in the treatment of leukaemia. Formula: C5H4N4S
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.mercaptopurine - a drug (trade name Purinethol) that interferes with the metabolism of purine and is used to treat acute lymphocytic leukemia
antimetabolite - an antineoplastic drug that inhibits the utilization of a metabolite
References in periodicals archive ?
Mercaptopurine is an immunosuppressive medication used to treat leukaemia patients.
A few studies have indicated that mercaptopurine treat AZA's gastric intolerance in patients with IBD [22].
Moreover, trans effects of single-nucleotide polymorphisms that affect TPMT activity and mercaptopurine sensitivity have recently been discovered in the PACSIN2 (protein kinase C and casein kinase substrate in neurons 2) gene.
Febuxostat is contraindicated in patients being treated with azathioprine, mercaptopurine, or theophylline.
13,15) Recently, mercaptopurine has been also implicated in inducing a secondary malignancy.
Her history included a diagnosis of Crohn disease in 1978 and treatment with glucocorticoids, cyclosporine, and mercaptopurine.
Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity.
Thiopurines are a class of drugs that include azathioprine and mercaptopurine.
This test expands upon the group of chemotherapeutic TDM tests already offered by NMS Labs which includes Busulfan, Mercaptopurine, Mitotane, Platinum and Tamoxifen and metabolites.
The investigation will look into the pricing practices for the company's niche medicines that contain the active pharmaceutical ingredients chlorambucil, melphalan, mercaptopurine, tioguanine and busulfan.
Background & objectives: Mercaptopurine, azathioprine, and thioguanine, used as antineoplastic agents and immunosuppressants are catabolized by thiopurine methyltransferase (TPMT) enzyme, which exhibits genetic polymorphism.