, which is a chemotherapy drug, run out at KNH which treats about 90 per cent of cancer patients in public hospitals, putting the lives of those suffering from leukaemia at risk.The shortage started in August.
Mutie further explained that there is only one brand of Mercaptopurine
that is registered for use in the Kenya but the drug is currently unavailable in the country.
In addition, because the AEs continued in 2 patients, the treatment was changed to mercaptopurine
Garcia-Plaza, "Efficacy and safety of thiopurinic immunomodulators (azathioprine and mercaptopurine
) in steroid-dependent ulcerative colitis," Alimentary Pharmacology and Therapeutics, vol.
is an immunosuppressive medication used to treat leukaemia patients.
The patients who discontinued the treatment with AZA, were treated with mercaptopurine
. The results of this research showed that treatment with AZA proved efficient against idiopathic inflammatory diseases (IID), despite the side effects, which can be treated by replacing the drug with mercaptopurine
This disease cannot be cured, but can often be managed through a range of treatments including liquid diets, steroid courses and treatments such as Infliximab infusions and Mercaptopurine
(which is used in chemotherapy).
She had a history of Crohn's disease treated with mercaptopurine
and mesalamine, hysterectomy because of uterine cancer, thyroidectomy, hypertension treated with lisinopril, coronary artery disease, hyperlipidemia, chronic renal disease with microhematuria, obesity, and depression treated with fluoxetine.
Elgemeie, "Thioguanine, mercaptopurine
: their analogs and nucleosides as antimetabolites," Current Pharmaceutical Design, vol.
Two brothers with skewed thiopurine metabolism in ulcerative colitis treated successfully with allopurinol and mercaptopurine
For this purpose, daily oral mercaptopurine
, once weekly oral methotrexate, once monthly 5-day course of intravenous vincristine and oral corticosteroids are usually used.
The GBTLI-99 protocol (Brazilian Group of Childhood Leukemia Treatment) comprises the administration of mercaptopurine
(50 mg x [m.sup.2] x [day.sup.-1]) and methotrexate (25mg x [m.sup.2] x [week.sup.-1]).