mersalyl


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mersalyl

(məˈsælɪl)
n
(Pharmacology) a salt of sodium, C13H16HgNNaO6, which was formerly used as a diuretic
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MI component Inhibitor Complex I Rotenone Complex II Atpenin A5 Complex III Antimycin Complex IV Na cyanide ANT Carboxyatractyloside ATP synthase Oligomycin Pi transporter Mersalyl Sum 1, 3-7 Total (NADH) Sum 2-7 Total (succinate) MI component Range of inhibitor concentration HCC Complex I 1-100 nM 0.56 Complex II 0.1-6 [micro]M 0.12 Complex III 1-200 nM 0.68 Complex IV 0.1-40 [micro]M 0.31 ANT 1-200 nM 0.28 ATP synthase 1-600 nM 0.25 Pi transporter 1-200 [micro]M 0.43 Sum 1, 3-7 2.08 Sum 2-7 2.07 MI component FCC Control colon tissue (mucosa) HBC Complex I 0.45 0.46 * Complex II 0.13 0.28 Complex III 0.66 0.54 * Complex IV 0.50 0.74 * ANT 0.97 1.02 * ATP synthase 0.24 0.61 * Pi transporter 0.53 0.60 * Sum 1, 3-7 2.82 3.36 Sum 2-7 3.03 3.78 Note: * from [26].
We could not find any information about CT activity in AD, whereas ANT activity is noticeably inhibited by A[beta] or hyperphosphorylated tau and this effect is reversed by mersalyl, a reversible alkylating agent of thiol groups [162].