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 (mĕz′ĕn-sĕf′ə-lŏn′, mĕs′-)
The midbrain.

mes′en·ce·phal′ic (-sə-făl′ĭk) adj.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
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As the wall of mesencephalon became much thickened, the mesocaele was reduced to a narrow canal called the mesencephalic acquiduct.
There are four central brain stem nuclei that are (1) mesencephalic nucleus, mediating proprioception (2) main sensory nucleus, mediating tactile sensation (3) the motor nucleus provides motor innervation and (4) the spinal nucleus mediates pain and temperature sensation.
This rhythmic stepping pattern is produced in the mesencephalic locomotor region, which contains the pedunculopontine nucleus (PPN).
owns key intellectual property rights and licenses from a number of prominent universities related to the development of the therapeutic protein known as mesencephalic astrocyte-derived neurotrophic factor.
However, recent in vitro and in vivo data have demonstrated that CysC played protective roles via pathways that were dependent on inhibition of cysteine proteases, such as cathepsin B, or by induction of autophagy, induction of proliferation, and inhibition of amyloid-beta aggregation.[9] For instance, Xu et al .[11] reported that loss of dopaminergic neurons in cultures of rat fetal mesencephalic cells exposed to 6-OHDA could be partially reversed by treatment with human CysC.
Protective effects of 1 alpha, 25-(OH)(2) D(3) against the neurotoxicity of glutamate and reactive oxygen species in mesencephalic culture.
elegans advancing the orphan drug-designated therapeutic protein mesencephalic astrocyte-derived neurotrophic factor (MANF) as a disease-modifying treatment for orphan ophthalmological conditions, glaucoma and Parkinson's disease.
[5] Studies have found that MA can increase glutamate neurotransmitters from the cortex to substantia nigra striatum and mesencephalic limbic system, and also increase dopaminergic neurotransmitters in the mesencephalon-cortex pathway; however, excessive glutamate and dopamine in the cerebral cortex exceed the inhibitory effect of GABA, thereby causing the presence of psychotic symptoms.
In previous studies, the blockade of [K.sub.ATP] channels protects the dopamine neurons from degeneration; however, the activation of [K.sub.ATP] channels can also protect mesencephalic neurons from MPP+ cytotoxicity [10, 11].
For the NeuriTox test (= UKN4), LUHMES (Lund human mesencephalic) cells were characterized and cultured as described in detail earlier (Krug et al., 2013; Lotharius et al., 2005; Scholz et al., 2011).
The aim of the present study was to analyse the astrocytic reaction following transplantation of embryonic mesencephalic tissue in a model of Parkinson's disease.