There is very rare expression of NTRK fusion but in various adult and pediatric solid tumors, including infantile fibrosarcoma, glioma, glioblastoma, diffuse intrinsic pontine glioma (DIPG), congenital mesoblastic
nephroma, melanoma, inflammatory myofibroblastic tumor (IMT), uterus sarcoma, soft tissue tumor, gastrointestinal stromal tumor (GIST), secretory carcinoma of breast, secretory carcinoma of salivary gland, cancer of unknown primary, lung cancer, colorectal cancer, appendiceal cancer, breast cancer, gastric cancer, ovarian cancer, thyroid cancer, cholangiocarcinoma, pancreatic cancer, head and neck cancer, and various sarcomas.
Two cases each of urothelial carcinoma of the renal pelvis, squamous cell carcinoma and one case of mesoblastic
nephroma were the other tumours recorded in the study.
Tumor types included 10 distinct soft tissue sarcomas, salivary gland, infantile fibrosarcoma, thyroid, lung, melanoma, colon, gastrointestinal stromal tumor, breast, bone sarcoma, cholangiocarcinoma, carcinoma of unknown primary, congenital mesoblastic
nephroma, appendiceal, and pancreas cancers.
Detection of the ETV6-NTRK3 chimeric RNA of infantile fibrosarcoma/cellular congenital mesoblastic
nephroma in paraffin-embedded tissue: application to challenging pediatric renal stromal tumors.
Different types of pediatric renal tumors are known, the commonest of which is Wilms tumor or nephroblastoma, other less common tumors are nephroblastomatosis, rhabdoid malignant tumor, clear cell sarcoma, congenital mesoblastic
nephroma and multilocular cystic nephroma3.
Previously, the ETV6-NTRK3 translocation has been described in infantile fibrosarcoma (11), congenital mesoblastic
nephroma, and acute myelogenous leukaemia (2, 7, 8).
While differential diagnosis included a blastemal predominant Wilms Tumor and congenital mesoblastic
nephroma, the tumor was determined to be most consistent with a rare ossifying renal tumor of infancy.
nephroma (CMN), the most common congenital renal neoplasm, also shows a biphasic architecture with cysts and tubules embedded in abundant spindle cell stroma and, hence, is morphologically very similar to MEST.
fibrous strings and amnionic bands: Associated constricting fetal malformations or fetal death.
Such idea is not new in the biological sciences, and a classification of this type was proposed by Whitney, in 1901, identifying cancerous tissues as epiblastic, mesoblastic
, and hypoblastic .
Alon, "Parathyroid-hormone-related protein-mediated hypercalcemia in benign congenital mesoblastic
nephroma," Pediatric Nephrology, vol.
Differentials for a cystic-solid abdominal mass with calcifications in neonates and early infancy include mesoblastic
nephroma, neuroblastoma, gastrointestinal stromal tumors, lymphangiomas, and teratomas.