The immunohistochemistry staining by CK7, CAM5.2, 34 beta E12, CEA, C-A125, Leu-M1 and Vimentin (positivity), P53 and Bcl-2 (overexpression) and CK20, [beta]-HCG and Alpha 1-fetoprotein (negative staining) are suggestive for CCC and could distinguish this malignancy from other differential diagnoses such as Aria-Stella reaction, micro glandular hyperplasia, and mesonephric
hyperplasia in adults, and Yolk sac tumor, sarcoma botryoides, and embryonal rhabdomyosarcoma in children, and metastatic renal cell carcinoma in all ages.
It is believed to be a congenital malformation, caused by failure of the ureter to separate from the mesonephric
duct during development.
The most common histological description of NA is presence of tubular structures resembling mesonephric
carcinoma of the endocervix is a rare malignancy arising from remnants of the Wolffian duct system, in contrast to many other neoplasms of the gynecologic tract, which are Mullerian derived.
The pathological result was surprising--Microscopy: ovarian and tubal fragments (containing many mesonephric
debris) with diffuse carcinoma infiltration with trabecular and cordial architecture and discoesic alveolus, reduced associated stroma and major edema.
The uterus is the most important reproductive organ present in the pelvis, a constituent of the internal female reproductive tract which develops from a paired paramesonephric duct, originating from coelomic epithelium extending beside the mesonephric
Midline-derived Shh regulates mesonephric
tubule formation through the paraxial mesoderm.
The Wolffian (mesonephric
) and Mullerian (paramesonephric) ducts form in both sexes.
The cells are thought to be trapped in WJ during the early stage of embryogenesis, when they migrate from the aortic gonadotropin mesonephric
region to the fetal liver through the umbilical cord .
Whether these remnants are mesonephric
or mullerian in origin is not known.
It was used to be called adnexal papillary tumor of probable mesonephric
Originally, these neoplasms were referred to as "mesonephric
carcinoma," since they were thought to arise from mesonephric