'On July 7, her condition took a turn for the worse and she had difficulty breathing, she was diagnosed as having septicaemic shock secondary to right lobar pneumonia and measles with metabolic acidosis
and was referred to the Sultanah Nur Zahirah Hospital, Terengganu,' he told reporters after officiating the Simulation and Skills Training Centre at the Specialist Complex and Ambulatory Care Centre, Kuala Lumpur Hospital here today.
Separate chapters address disorders of plasma sodium concentration, potassium homeostasis, metabolic acidosis
and alkalosis, nephrotic syndrome, diabetic kidney disease, macrovascular diseases, and the kidney during pregnancy.
Initial investigations showed normal blood biochemistry except for high anion gap metabolic acidosis
having pH of 7.1.
Tricida is a pharmaceutical company focused on the development and commercialization of its drug candidate, TRC101, a non-absorbed, orally-administered polymer designed to treat metabolic acidosis
in patients with chronic kidney disease.
The presence of metabolic acidosis
in cord blood with pH <7 is higly suggestive of HIE.
Tricida announced results from its blinded, randomized, placebo-controlled, multicenter clinical trial, TRCA-301E, in 196 CKD patients with metabolic acidosis
. TRC101 represents a first-in-class drug candidate for the treatment of metabolic acidosis
, a chronic condition commonly caused by CKD that is believed to accelerate the progression of CKD, increase the risk of muscle wasting and cause the loss of bone density.
Ture and colleagues did a cross-sectional study to assess the frequency of metabolic acidosis
in patients who were taking topiramate.
'In our assessment the patient (Sharif) has stage 3 CKD problem, secondary to diabetic nephropathy and HTN, uncontrolled HTN and mild proteinuria, suboptimal T2 diabetes control, metabolic acidosis
, post-nasal drip and nasal allergies, fatty liver, nephrolithiasis and benign renal cysts, rule out secondary hyperparathyroidism and bone disease, and underling IHD with recent rise in Trop T level,' the report stated.
A number of studies indicate that the presence of metabolic acidosis
is associated with high mortality (4-7).
Most of the laboratory tests demonstrated no obvious abnormalities; however, and blood gas analysis revealed decompensated metabolic acidosis
(pH: 7.13; PaCO[sub]2: 13 mmHg [1 mmHg = 0.133 kPa]; and BEb: -22.7 mmol/L).
(2) first described the disorder in a 7-month-old boy with metabolic acidosis
The occurrence of metabolic acidosis
during pregnancy necessitates prompt evaluation and intervention taking into account the potential risks of poor maternal and/or fetal outcomes.