metabotropic receptor

Related to metabotropic receptor: Metabotropic glutamate receptor

metabotropic receptor

(mɪˌtæbəˈtrɒpɪk)

(Physiology) physiol an indirect receptor which initiates an intracellular biochemical cascade after it is triggered by an agonistic ligand. Compare ionotropic receptor

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ionotropic receptor

References in periodicals archive ?

The role played by glutamate in the mechanism and progression of PD via various ionotropic and metabotropic receptor types in the basal ganglia motor loop has been extensively investigated.

Current Nondopaminergic Therapeutic Options for Motor Symptoms of Parkinson's Disease

Glutamate can also bind to a metabotropic receptor.

What is an "addiction memory"?

1] is a G-protein-coupled metabotropic receptor that increases activity of the enzymes adenylyl cyclase and phospholipase C.

Neurotransmitters of the Brain: Serotonin Noradrenaline (Norepinephrine), and Dopamine

GPCRs are sometimes called metabotropic receptors because their action is mediated by metabolic functions (eg, enzyme activation).

How Cells Communicate, Part 3: How Cells Respond to Signals

Twenty chapters are divided into four parts: neurons: excitable and secretory cells that establish synapses; ionotropic and metabotropic receptors in synaptic transmission; somato-dendritic processing and plasticity of postsynaptic potentials; the hippocampal network.

Cellular and Molecular Neurophysiology, 4th Edition

Two classes of glutamate receptors exist: ionotropic receptors (iGluRs), and metabotropic receptors (mGluRs).

Panel of Six New Anti-Glutamate Receptor Antibodies from AbboMax and Their Function in the Central Nervous System and Other Organs

Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization.

Antinociceptive effects of oxymatrine from Sophora flavescens, through regulation of NR2B-containing NMDA receptor-ERK/CREB signaling in a mice model of neuropathic pain

The hypothesis that metabotropic receptors make a greater contribution to the process of learning is compatible with the idea of the more essential role of this type of receptor, compared to ionotropic ones, in the dynamics of nerve component plasticity (Eccles & McGreer, 1979).

The effects of agonists of ionotropic [GABA.sub.A] and metabotropic [GABA.sub.B] receptors on learning

Metabotropic receptors generally produce slower and longer-lasting reactions at the synapse that have modulatory effects rather than generate new nerve signals.

How adaptation of the brain to alcohol leads to dependence: a pharmacological perspective

So-called metabotropic receptors , responding to the same neurotransmitters, set off chemical cascades in the receiving nerve cells, so-called "second messenger" systems, chains of chemical processes activating synthesis of neurotransmitters, of receptors and of modulators, changing the reactivity of the nerve cell and of the system it subserves.