metachromatic


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met·a·chro·ma·tism

 (mĕt′ə-krō′mə-tĭz′əm)
n.
A change in color caused by variation of the physical conditions to which a body is subjected, especially such a change caused by variation in temperature.

met′a·chro·mat′ic (-măt′ĭk) adj.

metachromatic

(ˌmɛtəkrəʊˈmætɪk)
adj
1. (Biology) (of tissues and cells stained for microscopical examination) taking a colour different from that of the dye solution
2. (Biology) (of dyes) capable of staining tissues or cells a colour different from that of the dye solution
3. (Biology) of or relating to metachromatism
References in periodicals archive ?
Orchard Therapeutics PLC -- ADR (NASDAQ: ORTX) -- Phase 2 data for OTL-200 in metachromatic leukodystrophy
Orchard Therapeutics announced results from an integrated data analysis of OTL-200, a gene therapy in development for the treatment of metachromatic leukodystrophy at the San Raffaele-Telethon Institute for Gene Therapy.
Additional programs for neurometabolic disorders, primary immune deficiencies and hemoglobinopathies are all based on lentiviral vector-based gene modification of autologous HSCs and include three advanced registrational studies for metachromatic leukodystrophy (MLD), ADA-SCID and Wiskott-Aldrich syndrome (WAS), clinical programs for X-linked chronic granulomatous disease (X-CGD), transfusion-dependent beta-thalassemia (TDT) and mucopolysaccharidosis type I (MPS-I), as well as an extensive preclinical pipeline.
Inthe model group, microvilli in the epithelium of small intestine were sloughed and water-structure emerged, mitochondria of epithelial cells stretched, endochylema dissolved and partly collapsed, cell edge metachromatic stained and centralized to one side, partial nucleus swelling and karyorrhexis, and the inter space between cells were obvious.
These disorders include Alzheimer's disease, Parkinson's disease, Lewy body dementia, frontal temporal dementia, metachromatic leukodystrophy, Huntington's chorea, temporal lobe epilepsy, stroke, xenomelia, reduplicative phenomena, etc.
As a result, two known mutations (c.114C>T; p.Arg372Trp and c.418dupC; p.His140Profs36*) were identified in the ARSA gene that led to metachromatic leukodystrophy (MLD) with combined heterozygosity.
Les Martin's world was turned upside down when Cathal, five, and three-yearold Ciaran were diagnosed with metachromatic leukodystrophy - an illness for which there is no cure.
The company plans to enroll 12 patients in the ongoing Phase 2 study in inherited metabolic disorders, which include cALD, Hurler syndrome, metachromatic leukodystrophy and globoid cell leukodystrophy.
The firm plans to enrol 12 patients in the ongoing Phase two study of inherited metabolic disorders including cALD, Hurler syndrome, metachromatic leukodystrophy and globoid cell leukodystrophy.
Metachromatic leukodystrophy (MLD) and Krabbe's disease are autosomal recessive disorders caused by lysosomal enzyme deficiency.
No metachromatic reaction with toluidine blue or cells with active caspase-1 was detected in the skin of the infected fish (data not shown).