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 (mĭ-tăl′ə-prōt′n-ās′, -āz′, -prō′tē-nās′, -nāz′)
Any of a group of proteolytic enzymes whose catalytic activity depends on the presence of a metal ion in the active site, especially any of those (called "matrix metalloproteinases") that degrade proteins in the extracellular matrix.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
References in periodicals archive ?
Urinary matrix metalloproteinase activities: biomarkers for plaque angiogenesis and nephropathy in diabetes.
KEYWORDS: Squamous cell carcinoma, Matrix metalloproteinase, Enzyme-linked immunosorbent assay.
Matrix Metalloproteinase enzymes (MMPs) were discovered, in 1962, by Jerome Gross and Charles M.
Their topics include naturally occurring matrix metalloproteinase inhibitors: a group of promising cardioprotective agents, natural products against drug-induced cardiotoxicity, the role of dietary supplements in cardiovascular disease, and the beneficial role of antioxidant molecules with therapeutic potential in cardiac disease.
Inflammation is characterized by dysregulation of MMP-tissue inhibitor of metalloproteinase (MMP-TIMP) interaction, increase in vascular endothelial growth factor A (VEGFA, a protein encoded by VEGFA) expression, and increase in transforming growth factor-beta (TGF-[beta], a polypeptide cytokine) signaling (8).
Following ECVC challenge, there was a significant increase in secretion of interleukin 6, tumor necrosis factor ?, CXCL-8, monocyte chemoattractant protein 1, and matrix metalloproteinase 9.
The matrix metalloproteinase system: changes, regulation, and impact throughout the ovarian and uterine reproductive cycle.
FCX-013 is an autologous fibroblast genetically modified to express matrix metalloproteinase 1, a protein responsible for breaking down collagen.FCX-013 incorporates Intrexon Corporation's proprietary RheoSwitch Therapeutic System, a biologic switch activated by an orally administered compound to control protein expression.
Increased serum levels of MMP-9 and decreased levels of tissue inhibitor of metalloproteinase 1 (TIMP-1) were found in children who experienced acute encephalopathy following prolonged febrile seizures [106].
Clinical significance of mucin phenotype, beta-catenin and matrix metalloproteinase 7 in early undifferentiated gastric carcinoma.
Murphy, "Metalloproteinase inhibitors: biological actions and therapeutic opportunities," Journal of Cell Science, vol.
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