(3-11) These tumors have been published under the following names in the literature: leiomyomatous renal hamartomas, congenital mesoblastic nephroma in an adult, cystic hamartoma of renal pelvis, solitary multilocular cysts of the kidney, multilocular renal cyst with mullerian-like stroma, and adult metanephric
Dysplastic changes are defined as altered metanephric
differentiation during embryogenesis, leading to abnormal kidney.
adenosarcoma in a young adult: morphologic, immunophenotypic, ultrastructural, and fluorescence in situ hybridization analyses: a case report and review of the literature.
The differential diagnosis for mesoblastic nephroma includes Wilms tumor, clear cell sarcoma, rhabdoid tumor, and metanephric
Wilms tumor occurring in the kidney is thought to arise from aberrant differentiation of persistent metanephric
mesenchyme. Although the exact histogenesis of EWT is unclear, origin from persistent embryonic nests of primitive renal anlage is favored.
Even though the prototype tumor with papillary pattern is papillary RCC (Figure 2, A and B), a variety of renal neoplasms can have papillary architectures; these include clear cell (Figure 2, C), clear cell papillary (Figure 2, D), and rarely chromophobe (Figure 2, E), and mucinous tubular spindle cell RCCs, collecting duct carcinoma (Figure 2, F), as well as metanephric
adenoma or metastatic carcinoma.
Gene expression in Wilms' tumour mimics the earliest committed stage in the metanephric
In B, urogenital system showing the syntopy of the organs, metanephric
(MT), Ovary (O), uterine horn (Co), bladder (Bx), urethra (U) and external genitalia (Gex).
Single vaginal ectopic ureter of fetal metanephric
duct origin, ipsilateral kidney agenesis, and ipsilateral rudimentary uterine horn of the bicornuate uterus.
The tumor consisted in tumor epithelial component (abortive tubules and glomeruli) surrounded by metanephric
blastema and tumor immature spindled cell stroma without any anaplasia or emboli of tumor cells.
The excretory units composed of the glomeruli and the collecting system originate from the metanephric
mesoderm and ureteric bud, respectively.
Redefining the in vivo origin of metanephric
nephron progenitors enables generation of complex kidney structures from pluripotent stem cells.