Am, amniotic cavity; db, decidua basalis; L, Labyrinth; Mt, metanephros
; Ms, mesonephros.
Among the neoplasms, Wilms tumor is the commonest renal tumor of childhood representing approximately 10% of all childhood malignancies that arises from embryological precursors of renal parenchyma (metanephros
) with a peak incidence between 3-4 years; it is uncommon above the age of 5 and is rare in neonates1.
Pronephros, mesonephros, and metanephros
represent the three primitive kidneys, present during the various developmental stages of the human embryo.
According to the most accepted theory, the kidney reaches the adult location at the eighth gestational week followed by the superior accelerated migration of the metanephros
and the delay in mesonephros involution before completing the diaphragmatic development, that is, before the fusion of the pleuroperitoneal membrane.
In this study, we aimed to explore the effects of CsA on metanephros
development in the pregnant BALB/c mice.
As the kidney ascends, the arterial degeneration begins at the cephalad end of the metanephros
, the segmental branch to the lower pole is the one most likely to persist as an accessory vessel (Graves 1969).
This set of genes is known to have a direct effect on the process of cell proliferation involved in metanephros
development of the kidney.
The embryologic explanation of these variations has been presented and discussed by Felix.[sup] According to him, the developing mesonephros, metanephros
, and gonads are supplied by nine pairs of lateral mesonephric arteries arising from the dorsal aorta.
The future kidney that is the metanephros
was observed for changes and diameter and epithelial height of proximal tubules was measured at 40X after calibrating ocular micrometer (Figure 1).