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Related to metastatic cascade: metastatic tumor, intravasation


n. pl. me·tas·ta·ses (-sēz′) Medicine
1. Transmission of pathogenic microorganisms or cancerous cells from an original site to one or more sites elsewhere in the body, usually by way of the blood vessels or lymphatics.
2. A secondary cancerous growth formed by transmission of cancerous cells from a primary growth located elsewhere in the body.

[Greek, from methistanai, to change : meta-, meta- + histanai, to cause to stand, place; see stā- in Indo-European roots.]

met′a·stat′ic (mĕt′ə-stăt′ĭk) adj.
met′a·stat′i·cal·ly adv.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Adj.1.metastatic - relating to or affected by metastasis; "metastatic growth"


adj metastásico
References in periodicals archive ?
There is an ever-increasing body of evidence that additional CTC subsets that are not identifiable by epithelial biomarkers play myriad roles in the metastatic cascade, notably from metastatic tumor initiation to organ-specific colonization (11, 12).
They found also that the levels of TFF3 expression in the primary tumor were associated strongly with its level in the corresponding metastatic cells and the level was increased as the tumor cells moved along the metastatic cascade from the primary tumor.
The company's development strategy is based on identifying patients at risk from aggressive cancer and targeting the underlying mechanisms that drive the metastatic cascade. MetaStat is based in Boston, MA.
Macrophages can promote each step of the metastatic cascade, which we will discuss in more detail in the following sections.
Its product development strategy is based on identifying patients most at risk for cancer metastasis and targeting the underlying mechanisms that drive the metastatic cascade.
Tumor heterogeneity results from genetic and epigenetic alterations that enhance the plasticity and fitness of cancer cells in the face of hurdles like the metastatic cascade and anti-cancer therapies.
This novel understanding of the energetic requirements of cancer cells in the metastatic cascade informs on new approaches to target them specifically," says Valerie LeBleu, PhD, assistant professor of cancer biology at MD Anderson and lead author of the paper, published September 21, 2014 in Nature Cell Biology.
Many stages of the metastatic cascade involve cellular interactions mediated by cell surface components, such as carbohydrate-binding proteins, including galactoside-binding lectins (galectins).

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