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A folate antagonist, C20H22N8O5, that inhibits DNA synthesis and is used to treat psoriasis, certain cancers, and some inflammatory diseases such as rheumatoid arthritis. It is sometimes used in combination with misoprostol to induce abortion in early pregnancy.
(Pharmacology) an antimetabolite drug used in the treatment of certain cancers. Formula: C20H22N8O5
meth•o•trex•ate(ˌmɛθ oʊˈtrɛk seɪt)
a toxic folic acid analogue, C20H22N8O5, that inhibits cellular reproduction and is used in the treatment of psoriasis and certain cancers.
[1950–55; metho (xy)- + trexate, of unclear derivation]
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|Noun||1.||methotrexate - toxic antimetabolite that limits cellular reproduction by acting as an antagonist to folic acid; used to treat certain cancers and psoriasis and rheumatoid arthritis|
antimetabolite - an antineoplastic drug that inhibits the utilization of a metabolite