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A folate antagonist, C20H22N8O5, that inhibits DNA synthesis and is used to treat psoriasis, certain cancers, and some inflammatory diseases such as rheumatoid arthritis. It is sometimes used in combination with misoprostol to induce abortion in early pregnancy.

[methotre- (probably shortening and alteration of methylaminopterin, one of its chemical names : methyl + aminopterin) + perhaps (o)x(y)- + -ate.]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(ˌmɛθəʊˈtrɛkseɪt; ˌmiːθəʊ-)
(Pharmacology) an antimetabolite drug used in the treatment of certain cancers. Formula: C20H22N8O5
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014


(ˌmɛθ oʊˈtrɛk seɪt)

a toxic folic acid analogue, C20H22N8O5, that inhibits cellular reproduction and is used in the treatment of psoriasis and certain cancers.
[1950–55; metho (xy)- + trexate, of unclear derivation]
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.methotrexate - toxic antimetabolite that limits cellular reproduction by acting as an antagonist to folic acid; used to treat certain cancers and psoriasis and rheumatoid arthritis
antimetabolite - an antineoplastic drug that inhibits the utilization of a metabolite
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.


n metotrexato, metotrexate m
English-Spanish/Spanish-English Medical Dictionary Copyright © 2006 by The McGraw-Hill Companies, Inc. All rights reserved.
References in periodicals archive ?
The researchers found that compared with monotherapy of either methotrexate or a biologic, combination therapy with TNF or non-TNF biologics plus methotrexate improved disease control, remission, and functional capacity.
Release date- 23082019 - EMA has recommended new measures to prevent serious and potentially fatal errors with the dosing of methotrexate for treating inflammatory diseases such as rheumatoid arthritis, psoriasis and Crohn's disease.
- Irish drugmaker Horizon Therapeutics plc (NASDAQ: HZNP) has initiated a clinical trial evaluating Krystexxa (pegloticase injection) in combination with methotrexate as a strategy to increase the durability of response for patients living with chronic gout refractory to conventional therapies also known as uncontrolled gout, the company said.
Horizon Therapeutics, an Irish-tax registered pharmaceutical company, has started clinical trial assessing KRYSTEXXA (pegloticase injection) in combination with methotrexate as a strategy to increase the durability of response for patients living with chronic gout refractory to conventional therapies, also called uncontrolled gout, it was reported on Friday.
A second big trial designed to parallel CANTOS tested methotrexate in roughly the same way and found it produced no cardiovascular disease benefit among high-risk patients.
A 20% improvement in ACR criteria at week 24 --the primary endpoint of the randomized, controlled study--was significantly greater in 284 patients treated with etanercept monotherapy and in 283 patients treated with combination etanercept and methotrexate than in 284 patients treated with methotrexate monotherapy (60.9% and 65.0% vs.
Results: Patients were separated into two groups as those who were treated with single-dose methotrexate and those who required surgical treatment.
However at higher oncologic doses, as mentioned previously, it is this direct competition of folinic acid against methotrexate transport that allows it to be useful in the setting of MTX overdose.
Twelve days before presentation, she was diagnosed with palmoplantar psoriasis and placed on methotrexate 7.5 mg weekly along with folic acid 1 mg daily.
"To our knowledge, this is the first randomized controlled study of either adalimumab or methotrexate in children and adolescents with psoriasis," the researchers said, noting that the study did not include a placebo group because of ethical issues related to treating children with a severe chronic disorder.
Her past medical history was significant for paroxysmal atrial fibrillation for which she was taking apixaban, rheumatoid arthritis for which she was taking 7.5 mg methotrexate once a week for 6 years, coronary artery disease with left circumflex and right coronary artery stent placement 6 years ago, congestive heart failure with reduced ejection fraction for which she was taking digoxin and furosemide, diabetes mellitus type 2 on repaglinide, hypertension, and stage 4 chronic kidney disease secondary to diabetes and hypertension.