polyethylene glycol-epoetin beta - 75 mcg solution for injection 5;
1H-NMR data were consistent with structures 5a~f, for example, the 1H-NMR spectrum for compound 5c exhibits three sharp singlets at 3.526, 3.734, 3.792 ppm, corresponding to the methoxy
proton at ester group and to the methoxy
proton at quinazoline ring and benzene ring, respectively.
It can be described as a three-dimensional, highly branched, polyphenolic substance consisting of an irregular array of variously bonded "hydroxyl" and "methoxy
"-substituted phenyl propane units.
signal at 5H 3.82 (3H, s) attached to aromatic ring was also observed.
The [sup.1]H NMR spectrum of 3 displayed resonances for an aromatic proton [[[delta].sub.5]H 7.05 (1H, s, H-4)], two meta-coupled protons [5h 6.84 ([[delta].sub.H,] d, J = 2.0 Hz, H-5) and 7.03 (2H, d, J = 2.0 Hz, H-7)], an aromatic methyl [[[delta].sub.H] 2.28 (3H, s, 3-C[H.sub.3])], a methoxy
group [[[delta].sub.H] 3.88 (3H, s, 6-OC[H.sub.3])], and a [beta]-anomeric proton of a sugar moiety [[[delta].sub.H] 5.12 (1H, d, J = 8.0 Hz, H-1').
Particularly, a chemical component was found in heartwood and root; namely, (3R)-2',3',7-trihydroxy-4'- methoxyisoflavanone (40) displayed a Pf value 3-fold higher than positive control BHT and [alpha]-tocopherol in both concentrations 0.02% and 0.04%, which might be reasonable from three adjacent, two hydroxyl, and one methoxy
groups [19,20, 34].
University of Massachusetts scientists fabricated hydrogel microspheres by the electrostatic complexation of low methoxy
pectin and caseinate by decreasing the solution pH from 7 to 4.5.
groups at C-7 and C-ll of 11-O-methylWEL were located inside and outside the coumestan plane, respectively (Fig.
The contract has been signed for the commercialisation of Roche's prescription medicine Mircera (methoxy
polyethylene glycol-epoetin beta) in the US and Puerto Rico.
The signal due to methyl protons (ligand MPM) appeared as singlet at [delta] 2.37 and 2.44 ppm, whereas signal due to methoxy
protons appeared as singlet in the range [delta] 4.01-4.03 ppm.
Addition of a methoxy
group, in lieu of a hydroxyl group, to the terminal quinone of AQ resulted in an inhibitory anthraquinone, namely, 2MeO (Figure 2(c)).
The more fav ourabl e product was found to be the compound with the methoxy
group in ortho-position.