. One systematic review that looked at the efficacy of metoclopramide
for gastroparesis identified one small RCT and 3 smaller placebo-controlled crossover trials.
However, IV dexketoprofen seems to be faster and more effective than metoclopramide
In addition, Manaa and Seif found that the combination of Dexamethasone with Metoclopramide
was not significantly more effective than single administration of Dexamethasone in the prophylaxis of PONV in patients undergoing maxillofacial surgery.
The factors that increased the risk of a long hospital stay included patients with an ASA class 3, a history of previous acute cholecystitis, cholangitis, or pancreatitis, a history of cirrhosis, being on long-term anticoagulation with warfarin, having standard-pressure pneumoperitoneum (14mmHg), having been given metoclopramide
as an intraoperative antiemetic drug, having an intraoperative cholangiogram, having an operative time of more than 60 minutes, having an incidental perforation of the gallbladder, using an abdominal drain, PONV, an NRS pain score more than 3, a parenteral analgesia requirement of more than 2 doses, an oral analgesia requirement of more than 2 doses, complications, and private ward admission.
In this prospective, case-control study, we evaluated the efficacy of combined electroacupuncture/metoclopramide treatment with that of metoclopramide
only in improving gastric emptying in critically ill neurosurgical patients.
Material and Methods: Dose response curve of ranitidine and metoclopramide
were constructed by adding cumulatively increasing concentrations of the two drugs on isolated duodenum of rabbits separately.
In conjunction, a request for proprietary name review for Gimoti will be included if and when the company submits a New Drug Application (NDA) for EVK-001 (metoclopramide
Key clinical point: Intravenous metoclopramide
and diphenhydramine relieved headaches more effectively than did codeine in pregnant patients who presented urgently.
In adult rats, the rate of gastric emptying is modulated by properties of the diet, including its caloric content and osmotic properties. Delayed gastric emptying has been documented in severe head injuries and in such cases metoclopramide
has no significant prokinetic effect on gastric emptying.
The Question: Do metoclopramide
and domperidone increase breast milk production?
Malbora (1) and his colleagues reported metoclopramide
in addition to corticosteroid in the treatment of a patient with steroid refractory Diamond-Blackfan (D-B) anemia in the recent issue of the Journal (1).