in the treatment of blepharospasm: experience with the first three patients.
To test this application, the team added mexiletine
, a medication used to treat irregular heartbeats (arrhythmias), to their heart cells.
DIHS/DRESS is usually associated with only a limited number of drugs, including carbamazepine, phenytoin, phenobarbital, lamotrigine, dapsone, mexiletine
, salazosulfapyridine, allopurinol, and minocycline [1-4].
HCl (VWR, cat# M2040) was dissolved in normal saline (0.9%NaHCl), pH 7.
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A notable mention are the preventable causes of high DFT: medication (lidocaine, mexiletine
, moricizine, verapamil, venlafaxine, anesthetic agents--including propofol necessary for DFT testing, cocaine, sildenafil and amiodarone in chronic administration -acute i.v.
* Oxicam NSAIDs, allopurinol, azathioprine, Captopril, mexiletine
After that initial visit, the patient and family elected to try other pharmacologic options, including orphenadrine, dextromethorphan, and mexiletine
. The patient also received two ketamine infusions: 150 mg over one hour on 04/17/2014 and 360 mg over one hour on 09/04/2014.
Altinoz et al., "Neuroprotective effect of mexiletine
in the central nervous system of diabetic rats," Molecular and Cellular Biochemistry, vol.
Kurebayashi, "Effect of mexiletine
on dynamic allodynia induced by chronic constriction injury of the sciatic nerve in rats," Journal of Veterinary Medical Science, vol.
Clinical studies have shown that SSYX capsules can effectively treat premature ventricular contraction and alleviate premature ventricular contraction-related symptoms when compared with mexiletine
Antzelevitch, "Sodium channel block with mexiletine
is effective in reducing dispersion of repolarization and preventing torsade de pointes in LQT2 and LQT3 models of the long-QT syndrome," Circulation, vol.