Summary: The 2, 4-dichloracetophenone is a ketone aromatic empirical Oused as a starting point for the synthesis of antifungal products such as miconazole
, ketoconazole or itraconazole
ORAVI is a novel once-daily mucoadhesive tablet formulation of the antifungal agent miconazole
for the treatment of oropharyngeal candidiasis (OPC), a condition that occurs frequently in immunocompromised patients due to HIV, malignant tumours, etc.
Keywords: Pityriasis versicolor, susceptibility, disc diffusion, ketoconazole, fluconazole, miconazole
, Malassezia spp.
22 that the Food and Drug Administration has approved a supplemental New Drug Application to expand the use of Miconazole
cream 1% (Luzu) to include the following indications: the topical treatment of patients aged 12 years and older with athlete's foot (interdigital tinea pedis) and jock itch (tinea cruris) and of patients aged 2 years and older with ringworm (tinea corporis) caused by the organisms Trichophyton rubrum and Epidermophyton floccosum.
* Topical 2% miconazole
bid for 2 weeks has resulted in clearance rates as high as 88%.
* McKinley OTC - Product line of over-the-counter active ingredients for topical applications with anti-inflammatory (Hydrocortisone Base and Acetate), anti-fungal (Miconazole
Nitrate and Ketoconazole), anesthetic (Benzocaine, and Lidocaine HCL and Base), and anti-acne (Salicylic Acid) benefits.
nitrate, chemically 1-[(2RS)-2-[(2,4-dichlorobenzyl) oxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole nitrate, is an antifungal azole .
albicans is performed using systemic and topical antifungal, mainly from the group of azole drugs, the main representatives are ketoconazole, miconazole
, itraconazole, fluconazole, voriconazole and posaconazole, which have the same mechanism of action, inhibiting the synthesis of ergosterol.
glabrata showed the lowest susceptibility to fluconazole and miconazole
, and the highest to ketoconazole.
Topical therapy with clotrimazole 1% cream 5 mg once daily for 7-14 days, or miconazole
2% cream 5 mg once daily for 7 days can also be used.
Usually, denture stomatitis is treated with antifungals (miconazole
, nystatin, and fluconazole), but studies show cases of treatment failure and rapid recurrence after discontinuation of treatment, especially if not accompanied by proper prosthesis hygiene .
Conventional approaches include use of systemic antifungal drugs like Fluconazole and Miconazole
and topical agents such as Nystatin and Amphotericin B.4