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Here at Colleretto and in our other research centers, important projects are underway in the field of diagnostics--in Magnetic Resonance and ultrasound, in new treatment opportunities that are arising using microbubbles in combination with ultrasound and studies on assisted surgery, where our fluorescent probes are able to provide a significant contribution to therapy, especially in oncology.
Whilst the lifetime of macrobubbles (> 1 mm) is on the order of seconds and that of microbubbles (1-1000 microns) is on the order of minutes, nanobubbles do last for weeks and months.
With the noninvasive, convenient, and unique value in the quick diagnosis and dynamic monitoring during the course of treatment, bedside critical ultrasonography has been widely used, regarded as the 'visual stethoscope.' Contrast-enhanced ultrasonography (CEUS) is a competing technology that enables real-time observation of vascular perfusion; the basic composition of the contrast agents is microbubbles made of gases embedded within a shell characterized by safety, high tolerance, and lack of radiation, which can reflect ultrasound and avoid destruction during circulation and allow for continuous imaging of the vasculature and microcirculation.
Ultrasonography contrast agents consist of microbubbles, which are gas spheres of up to 10 mm in diameter, coated with a shell of different proteins, lipids, or polymers (25).
Nir Lipsman, M.D., of the Sunnybrook Health Sciences Centre at the University of Toronto, and colleagues say that magnetic resonance-guided focused ultrasound, when combined with injected microbubbles, transiently opens the blood-brain barrier with a high degree of spatial and temporal specificity.
Molecular imaging with US uses targeted or functionalized microbubbles as contrast agents.
The ultrasonic contrast agent containing microbubbles was delivered to tissues and organs through intravenous injection.
This major drawback is partially alleviated using an ultrasound contrast agent formed of gas microbubbles. The echogenicity of the microbubbles is immense in comparison to the echogenicity of the surrounding soft tissues.
The benefits of Promass Q Coriolis flowmeter include exceptional density measurement performance, widest useable flow range on the market, excellent performance for liquids containing suspended bubbles or microbubbles thanks to the patented "Multi-Frequency Technology", superior repeatability, e.g.
Researchers found that microbubbles conjugated to streptavidin can be coupled to the surface of a cell, where mechanosensitive Piezo1 ion channels are expressed.
Lyp-1 ultrasonic microbubbles targeting to cancer cell as tumor bio-acoustics markers or drug carriers: targeting efficiency evaluation in microfluidic channels, 31 (st) Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2009.
Among them, microbubbles have received much attention in the past decades, either for the energy that bubbles can release by cavitation [5-7] or for their utility as ultrasound contrast agents in medicine .
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