These new parameters include low hemoglobin density (LHD), microcytic anemia
factor, mean sphered cell volume, red cell size factor, immature reticulocyte fraction, mean reticulocyte volume, high-light-scatter reticulocytes, reticulocyte distribution width, and mean platelet volume.
A 69-year-old man presented with a long-standing thrombocytopenia and microcytic anemia
is seen in 6% of these patients (8).
Laboratory investigations were significant for hypochromic microcytic anemia
He is admitted to the hospital for severe microcytic anemia
and is found to have Cameron ulcers and antral erosions.
The RBC count is also useful as a differential tool because the thalassemias produce a microcytic anemia
with an associated increase in the RBC number, while the other causes of microcytic anemia
, including iron deficiency and anemia of chronic disease, are more typically associated with a decrease in the RBC number that is proportional to the degree of decrease in Hb concentration.
This is in harmony with the view of Bauer (24) who reported that a mild to moderate normochromic microcytic anemia
is seen in almost every patient with SLE.
9) However, Hb Hope has contributed to serious microcytic anemia
when inherited in combination with a particular version of [alpha]-thalassemia called Hemoglobin H disease.
5) By contrast, beta-thalassemia major (Cooley's anemia), an inherited microcytic anemia
, may be associated with iron overload, and levels of ferritin (an iron-storage protein) may be positively correlated with lipid peroxidation product concentrations in this disorder.
We describe a patient with a history of chronic microcytic anemia
with peripheral schistocytosis, polychromasia, and Pappenheimer bodies, treated empirically with chronic iron supplementation.
Treatment with prednisone and cyclophosphamide was unsuccessful and led to microcytic anemia
as a side effect.
A panoply of manifestations ranging from microcytic anemia
, abdominal pain, seizures, and even death may ensue.