The advance will allow biomedical scientists to study the functioning of an individual's intestinal lining in a controlled microenvironment
, where the lining can interact with immune cells, blood cells and drugs, said Robert Barrett of the Regenerative Medicine Institute.
M2 PHARMA-December 15, 2017-Bristol-Myers Squibb Granted Exclusive License by Ono Pharmaceutical for Multiple Programs Targeting Immuno-Suppressive Factors in the Tumor Microenvironment
Macrophage Pharma's Esterase Sensitive Motif (ESM) technology enables delivery of novel, small molecule drug candidates to tumor associated macrophages in a selective manner to reverse immunosuppression established in the tumor microenvironment
, and could progress to provide a next-generation immunotherapy with broad utility in oncology.
They discuss general principles of evolution and ecology as they apply to cancer, the molecular mechanisms that underlie genetic heterogeneity within tumors, roles of the microenvironment
and spatial heterogeneity within tumors that provide selection pressures and drive the coevolution of cancer cells with their microenvironment
, and examples of how to incorporate novel technologies such as liquid biopsy into clinical practice to detect and monitor tumors during treatment.
The therapy blocks suppressor cells and activates anti-tumour effector cells, transforming the microenvironment
of the tumour.
The combination phase of this ongoing Phase 1 study in patients with advanced solid tumors will explore the potential of combining these two agents to drive improved and sustained efficacy and tolerability above the current standard of care by targeting the immune-suppressive cells in the tumor microenvironment
4,5) According to the current study, the microenvironment
surrounding the tumor may also have a role.
This new platform utilizes microfluidic technology, which produces a realistic cell culture microenvironment
We found that fetal MuSCs remodel their microenvironment
by secreting specific proteins, and then examined whether that same microenvironment
can encourage adult MuSCs to more efficiently generate new muscle.
However, the application of RT is limited by the acquisition of radioresistance in cells, conferred by the tumor microenvironment
The compound works by changing a tumor's microenvironment
THREE-DIMENSIONAL TISSUE-ENGINEERED MODELS TO SIMULATE THE CANCER MICROENVIRONMENT